Advances in 3D skin bioprinting for wound healing and disease modeling.
Advances in 3D skin bioprinting for wound healing and disease modeling.
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DOI：
10.1093/rb/rbac105
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发表时间：
2023
影响因子：
6.7
通讯作者：
Huang, Sha
中科院分区：
文献类型：
--
作者：
Zhang, Mengde;Zhang, Chao;Li, Zhao;Fu, Xiaobing;Huang, Sha
尽管过去三十年来设计策略取得了许多进步，但现有的组织工程皮肤和天然皮肤之间仍然存在巨大差距。目前可用的体外皮肤模型仍然无法充分复制真皮微环境的三维性和异质性，以概括体内皮肤病症或疾病的许多已知特征。三维（3D）生物打印能够精确控制多种成分、空间分布和建筑复杂性，因此为填补天然皮肤和人造皮肤之间的结构和功能空白提供了希望。因此，体外模型的开发将促进我们对伤口愈合过程和皮肤疾病的理解，这些模型可以更完整地捕捉皮肤生物学的异质特征。在这里，我们概述了 3D 皮肤生物打印的最新进展，以及适合生物打印过程的细胞和生物墨水的设计概念。我们专注于该技术在工程生理或病理皮肤模型中的应用，更具体地关注皮肤附属器和脉管系统的功能。最后，我们总结了当前的挑战以及 3D 皮肤生物打印进一步发展的技术前景。
Even with many advances in design strategies over the past three decades, an enormous gap remains between existing tissue engineering skin and natural skin. Currently available in vitro skin models still cannot replicate the three-dimensionality and heterogeneity of the dermal microenvironment sufficiently to recapitulate many of the known characteristics of skin disorder or disease in vivo. Three-dimensional (3D) bioprinting enables precise control over multiple compositions, spatial distributions and architectural complexity, therefore offering hope for filling the gap of structure and function between natural and artificial skin. Our understanding of wound healing process and skin disease would thus be boosted by the development of in vitro models that could more completely capture the heterogeneous features of skin biology. Here, we provide an overview of recent advances in 3D skin bioprinting, as well as design concepts of cells and bioinks suitable for the bioprinting process. We focus on the applications of this technology for engineering physiological or pathological skin model, focusing more specifically on the function of skin appendages and vasculature. We conclude with current challenges and the technical perspective for further development of 3D skin bioprinting.
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