Recent advances on human milk oligosaccharide antimicrobial activity.

Recent advances on human milk oligosaccharide antimicrobial activity.
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DOI:
10.1016/j.cbpa.2022.102202
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发表时间:
2022-12
影响因子:
7.8
通讯作者:
--
中科院分区:
生物学2区
文献类型:
--
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在过去的世纪里,抗菌药物的发展促进了人类健康。随着20世纪40年代第一批抗生素的使用,细菌耐药性出现了,甚至越来越多地超过了最有前途的抗菌药物。因此,人们对规避抗微生物剂耐药性演变的替代方法越来越感兴趣。在所附的简短综述中,我们讨论了母乳的抗菌特性,特别强调母乳低聚糖(HMO)。我们回顾了革兰氏阴性和革兰氏阳性病原体的研究,强调了HMO在促进人类健康和健康方面的用途。
Over the past century, human health has been enhanced by antimicrobial development. Following the deployment of the first antibiotics in the 1940s, bacterial resistance emerged and has increasingly outmaneuvered even the most promising antimicrobial agents. Accordingly, increased interest has been placed on alternative methods to circumvent antimicrobial resistance evolution. In the enclosed short review, we discuss the antimicrobial properties of human breast milk with a special emphasis on human milk oligosaccharides (HMOs). We recount studies across gram-negative and gram-positive pathogens, highlighting the usage of HMOs in promoting human health and wellness.
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