The human neonatal gut microbiome: a brief review.
The human neonatal gut microbiome: a brief review.
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DOI：
10.3389/fped.2015.00017
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发表时间：
2015
影响因子：
2.6
通讯作者：
Bhandari V
中科院分区：
文献类型：
--
作者：
Gritz EC;Bhandari V
在过去的十五年中，基因组学领域已经扩展到了宏基因组学等亚专业。大规模并行测序能力的发展已经允许对人类微生物组的基因组进行越来越详细的研究，人类微生物组是共生地存在于人类宿主的粘膜组织和表皮系统内的微生物超级器官。肠道微生物组，特别是其在新生儿中的起源的研究，已成为基因组学领域内非常感兴趣的子主题。这篇简短的综述旨在总结有关新生儿肠道微生物组的起源和建立的最新文献，从子宫开始，以及它如何受到新生儿营养状况（母乳喂养与配方奶粉喂养）和胎龄（足月与早产）的影响。我们还探讨了微生态失调的作用，微生物群脆弱生态系统内的扰动，及其在选择病理状态起源中的作用，特别是早产儿肥胖和坏死性小肠结肠炎（NEC）。我们讨论的证据支持肠道益生菌和益生菌补充的肠道微生物，如双歧杆菌和乳酸杆菌在新生儿期，其作用在预防和改善NEC早产儿。最后，我们回顾了进一步研究的方向，以促进这一领域内的人类健康。
The field of genomics has expanded into subspecialties such as metagenomics over the course of the last decade and a half. The development of massively parallel sequencing capabilities has allowed for increasingly detailed study of the genome of the human microbiome, the microbial super organ that resides symbiotically within the mucosal tissues and integumentary system of the human host. The gut microbiome, and particularly the study of its origins in neonates, has become subtopics of great interest within the field of genomics. This brief review seeks to summarize recent literature regarding the origins and establishment of the neonatal gut microbiome, beginning in utero, and how it is affected by neonatal nutritional status (breastfed versus formula fed) and gestational age (term versus preterm). We also explore the role of dysbiosis, a perturbation within the fragile ecosystem of the microbiome, and its role in the origin of select pathologic states, specifically, obesity and necrotizing enterocolitis (NEC) in preterm infants. We discuss the evidence supporting enteral pre- and pro-biotic supplementation of commensal organisms such as Bifidobacterium and Lactobacillus in the neonatal period, and their role in the prevention and amelioration of NEC in premature infants. Finally, we review directions to consider for further research to promote human health within this field.
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DOI：
10.1136/archdischild-2011-300435
发表时间：
2013-01-01
影响因子：
4.4
作者：
Alberto Fernandez-Carrocera, Luis;Solis-Herrera, Aide;Leticia Echaniz-Aviles, Maria Olga
通讯作者：
Leticia Echaniz-Aviles, Maria Olga
影响因子：
7.1
作者：
Braga, Taciana Duque;Pontes da Silva, Giselia Alves;Lima, Marilia de Carvalho
通讯作者：
Lima, Marilia de Carvalho
影响因子：
4.3
作者：
Chen K;Pachter L
通讯作者：
Pachter L
影响因子：
17.1
作者：
Aagaard K;Ma J;Antony KM;Ganu R;Petrosino J;Versalovic J
通讯作者：
Versalovic J
影响因子：
2.9
作者：
Al-Hosni, M.;Duenas, M.;Soll, R.
通讯作者：
Soll, R.