Dimensional brain-behavior relationships in children with attention-deficit/hyperactivity disorder.
Dimensional brain-behavior relationships in children with attention-deficit/hyperactivity disorder.
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DOI：
10.1016/j.biopsych.2011.08.013
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发表时间：
2012-03-01
影响因子：
10.6
通讯作者：
Milham, Michael P.
中科院分区：
文献类型：
--
作者：
Chabernaud, Camille;Mennes, Maarten;Kelly, Clare;Nooner, Kate;Di Martino, Adriana;Castellanos, F. Xavier;Milham, Michael P.
关键词：
新兴的神经科学和遗传学发现强调精神疾病的维度而不是分类方面。然而，在目前的分类诊断框架内的整合维度的方法仍然不清楚。在这里，我们使用静息状态功能磁共振成像（R-fMRI），以检查是否维度的精神病学测量捕获脑行为的关系无法解释的分类诊断。此外，我们还研究了维度脑-行为关系是否因存在分类定义的疾病-注意力缺陷/多动障碍（ADHD）而改变。R-fMRI扫描收集了37名发育正常的儿童（年龄10.2±2岁; 21名女性）和37名符合DSM-IV-TR ADHD标准的儿童（9.7±2岁; 11名女性）。父母评定的儿童行为检查表外部化和内部化分数作为维度的措施，在我们的分析默认网络（DN）的静息状态功能连接（RSFC）。无论诊断如何，我们观察到DN RSFC与内在化和外在化评分之间存在一些显著关系。增加的内化分数与更强的阳性DN内RSFC相关，而增加的外化分数与DN和“任务阳性”区域（如背侧前扣带皮层）之间的负RSFC减少相关。这些脑行为关系中的几个取决于ADHD的分类存在。我们的研究结果表明，虽然分类诊断的界限提供了一个不充分的基础，了解精神疾病的病理生理，精神疾病不能简单地被视为一个极端的典型的神经或行为功能。理解精神疾病的神经基础的努力应该包括分类和维度的临床评估。
Emerging neuroscientific and genetic findings emphasize the dimensional rather than the categorical aspects of psychiatric disorders. However, the integration of dimensional approaches within the current categorical diagnostic framework remains unclear. Here, we used resting state fMRI (R-fMRI) to examine whether dimensional measures of psychiatric symptomatology capture brain-behavior relationships unaccounted for by categorical diagnoses. Additionally, we examined whether dimensional brain-behavior relationships are modified by the presence of a categorically defined illness, Attention-Deficit/Hyperactivity Disorder (ADHD). R-fMRI scans were collected from 37 typically developing children (aged 10.2±2; 21 females) and 37 children meeting DSM-IV-TR criteria for ADHD (9.7±2; 11 females). Parent-rated Child Behavior Checklist Externalizing and Internalizing scores served as dimensional measures in our analyses of default network (DN) resting state functional connectivity (RSFC). Regardless of diagnosis, we observed several significant relationships between DN RSFC and both Internalizing and Externalizing scores. Increased Internalizing scores were associated with stronger positive intra-DN RSFC, while increased Externalizing scores were associated with reduced negative RSFC between DN and “task-positive” regions such as dorsal anterior cingulate cortex. Several of these brain-behavior relationships differed depending on the categorical presence of ADHD. Our findings suggest that while categorical diagnostic boundaries provide an inadequate basis for understanding the pathophysiology of psychiatric disorders, psychiatric illness cannot be viewed simply as an extreme of typical neural or behavioral function. Efforts to understand the neural underpinnings of psychiatric illness should incorporate both categorical and dimensional clinical assessments.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
10.6
作者：
Fair, Damien A.;Posner, Jonathan;Nagel, Bonnie J.;Bathula, Deepti;Dias, Taciana G. Costa;Mills, Kathryn L.;Blythe, Michael S.;Giwa, Aishat;Schmitt, Colleen F.;Nigg, Joel T.
通讯作者：
Nigg, Joel T.
DOI：
10.1176/appi.ajp.2009.08121894
发表时间：
2009-08
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Di Martino A;Shehzad Z;Kelly C;Roy AK;Gee DG;Uddin LQ;Gotimer K;Klein DF;Castellanos FX;Milham MP
通讯作者：
Milham MP
影响因子：
2.9
作者：
Church, Jessica A.;Wenger, Kristin K.;Schlaggar, Bradley L.
通讯作者：
Schlaggar, Bradley L.
影响因子：
2.5
作者：
Andrews-Hanna, Jessica R.;Reidler, Jay S.;Buckner, Randy L.
通讯作者：
Buckner, Randy L.