Fructooligosaccharide (FOS) and Galactooligosaccharide (GOS) Increase Bifidobacterium but Reduce Butyrate Producing Bacteria with Adverse Glycemic Metabolism in healthy young population.
Fructooligosaccharide (FOS) and Galactooligosaccharide (GOS) Increase Bifidobacterium but Reduce Butyrate Producing Bacteria with Adverse Glycemic Metabolism in healthy young population.
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DOI：
10.1038/s41598-017-10722-2
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发表时间：
2017-09-18
影响因子：
4.6
通讯作者：
Zhou H
中科院分区：
文献类型：
--
作者：
Liu F;Li P;Chen M;Luo Y;Prabhakar M;Zheng H;He Y;Qi Q;Long H;Zhang Y;Sheng H;Zhou H
肠道微生物区系与糖耐量异常及其向2型糖尿病(T2 DM)的进展有关。与益生菌干预相关的随机临床试验是不够的。我们试图评估低聚果糖(FOS)和半低聚糖(GOS)在口服葡萄糖耐量试验(OGTT)和肠道微生物区系中对血糖的影响。35名成人随机双盲交叉服用果寡糖和果寡糖，疗程14天(16 g/d)。进行粪便采样、OGTT和人体测量参数。短期摄入大剂量益生元对糖代谢有不良影响，如口服葡萄糖耐量试验证实的低聚果糖干预(P <； 0.001)和空腹血糖证实的低聚果糖干预(P <； 0.05)。FOS组和GOS组的双歧杆菌相对丰度均显著增加，而FOS组和GOS组的丁酸产生菌如嗜丁酸杆菌和瘤胃球菌减少。使用初始微生物区系的随机森林模型被用来预测益生菌干预后的口服葡萄糖耐量试验水平，并取得了相对成功(R = 0.726)。我们的研究警告说，尽管FOS和GOS增加了双歧杆菌，但它们可能通过减少产生丁酸的微生物而对葡萄糖代谢产生不利影响。基于肠道微生物组的个体化益生元干预有待于今后的研究。
The gut microbiota has been implicated in glucose intolerance and its progression towards type-2 diabetes mellitus (T2DM). Relevant randomized clinical trial with prebiotic intervention was inadequate. We sought to evaluate the impact of fructooligosaccharides (FOS) and galactooligosaccharides (GOS) on glycemia during oral glucose tolerance test (OGTT) and intestinal microbiota. A randomized double-blind cross-over study was performed with 35 adults treated with FOS and GOS for 14 days (16 g/day). Faeces sampling, OGTT and anthropometric parameters were performed. Short-term intake of high-dose prebiotics had adverse effect on glucose metabolism, as in FOS intervention demonstrated by OGTT (P < 0.001), and in GOS intervention demonstrated by fasting glucose (P < 0.05). A significant increase in the relative abundance of Bifidobacterium was observed both in FOS and GOS group, while the butyrate-producing bacteria like Phascolarctobacterium in FOS group and Ruminococcus in GOS group were decreased. A random forest model using the initial microbiota was developed to predict OGTT levels after prebiotic intervention with relative success (R = 0.726). Our study alerted even though FOS and GOS increased Bifidobacterium, they might have adverse effect on glucose metabolism by reducing butyrate-producing microbes. Individualized prebiotics intervention based on gut microbiome needs to be evaluated in future.
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影响因子：
6.9
作者：
Daud, Norlida M.;Ismail, Nurhafzan A.;Frost, Gary S.
通讯作者：
Frost, Gary S.
影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
6.4
作者：
Delzenne NM;Neyrinck AM;Cani PD
通讯作者：
Cani PD
影响因子：
3.7
作者：
Larsen N;Vogensen FK;van den Berg FW;Nielsen DS;Andreasen AS;Pedersen BK;Al-Soud WA;Sørensen SJ;Hansen LH;Jakobsen M
通讯作者：
Jakobsen M
影响因子：
24.5
作者：
Dewulf EM;Cani PD;Claus SP;Fuentes S;Puylaert PG;Neyrinck AM;Bindels LB;de Vos WM;Gibson GR;Thissen JP;Delzenne NM
通讯作者：
Delzenne NM