Clinical and microbiological effects of localized ligature-induced periodontitis on non-ligated sites in the cynomolgus monkey.
Clinical and microbiological effects of localized ligature-induced periodontitis on non-ligated sites in the cynomolgus monkey.
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局部结扎诱发的牙周炎对食蟹猴非结扎部位的临床和微生物学影响。
DOI：
10.1111/j.1600-0765.1983.tb00353.x
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发表时间：
1983
影响因子：
3.5
通讯作者：
Robertson,PB
中科院分区：
文献类型：
--
作者：
Kiel,RA;Kornman,KS;Robertson,PB
这项研究的目的是在猴子模型系统中检测局部结扎诱导的牙周炎对非结扎部位的临床和微生物学影响。结扎诱导的牙周炎发生在每四只猕猴的一个象限。另外两只没有任何结扎的猴子作为对照。对结扎部位、非结扎部位和对照部位的临床情况和牙周微生物区系进行8-11周的监测。结扎部位最初(结扎后1-2周)炎症增加，革兰氏阴性表面转运菌(STB)和运动杆增加。临床和放射学证据表明，在结扎后4-6周，牙周附着丧失与牙周类杆菌比例增加有关。在整个实验期间，未结扎部位和对照部位没有表现出临床变化。然而，非结扎部位的革兰氏阴性STB和活动杆在4-6周时从4.6%增加到13.7%，在8-11周继续增加到20.3%。对照部位在实验期间没有出现微生物变化。在第二个实验中，细菌的纯培养。在不同时间，在未结扎的部位，将牙龈种植于龈下。只有增加的B比例才有可能恢复。种植时未结扎部位的牙周炎，而革兰氏阴性短杆菌和可动杆的比例增加。在植入后四周内，未结扎的感染部位未见附着丧失。
The purpose of this study was to examine the clinical and microbiological effects of localized ligature‐induced periodontitis on non‐ligated sites in a monkey model system. Ligature‐induced periodontitis was produced in one quadrant in each of fourMacaca fascicularismonkeys. Two additional monkeys without any ligatures served as control. The clinical condition and subgingival microflora of ligated, non‐ligated, and control sites were monitored for 8–11 weeks. Ligated sites demonstrated an initial (1–2 weeks post‐ligation) increase in inflammation, Gram‐negative surface translocating bacteria (STB), and motile rods. Clinical and radiographic evidence of loss of attachment associated with increased proportions ofBacteroides gingivaliswas evident 4–6 weeks post‐ligation. No clinical changes were demonstrated in non‐ligated and control sites throughout the experimental period. Non‐ligated sites, however, demonstrated an increase from 4.6% to 13.7% in Gram‐negative STB and motile rods by 4–6 weeks which continued to increase to 20.3%, by 8–11 weeks. Control sites showed no microbiological changes during the experimental period. In a second experiment pure cultures ofB. gingivaliswere implanted subgingivally at various times in non‐ligated sites. It was only possible to recover increased proportions ofB. gingivalisfrom non‐ligated sites when implantation occurred while proportions of Gram‐negative STB and motile rods were elevated. Loss of attachment in infected non‐ligated sites was not seen within four weeks of implantation.
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影响因子：
11.2
作者：
C. Osborne;C. Osborne;D. Boldt;G. Clark;J. Trent
通讯作者：
C. Osborne;C. Osborne;D. Boldt;G. Clark;J. Trent
正常和乳腺肿瘤小鼠的乳腺肿瘤病毒（MTV）抗原
影响因子：
6.4
作者：
J. Hilgers;G. J. Theuns;R. van Nie
通讯作者：
R. van Nie
感染乳源性小鼠乳腺肿瘤病毒的瑞士白化小鼠中病毒抗原的检测：年龄、性别和生殖状态的影响。
影响因子：
3.8
作者：
P. Osterrieth;S. Kozma;J. Hendrick;C. François;C. Calberg‐Bacq;P. Franchimont;L. Gosselin
通讯作者：
L. Gosselin
放射免疫分析小鼠器官和血清中鼠乳腺肿瘤病毒糖蛋白gp47，并在人血清中寻找相关抗原。
影响因子：
11.2
作者：
P. F. Zangerie;C. Calberg‐Bacq;C. Colin;P. Franchimont;C. François;L. Gosselin;S. Kozma;P. Osterrieth
通讯作者：
P. Osterrieth
DOI：
--
发表时间：
1981
期刊：
影响因子：
--
作者：
R. Tallarida;R. Murray
通讯作者：
R. Murray