Blocking the evolution of insecticide-resistant malaria vectors with a microsporidian.
Blocking the evolution of insecticide-resistant malaria vectors with a microsporidian.
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DOI：
10.1111/j.1752-4571.2011.00219.x
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发表时间：
2012-04
影响因子：
4.1
通讯作者：
Karacs TP
中科院分区：
文献类型：
--
作者：
Koella JC;Saddler A;Karacs TP
找到一种阻止杀虫剂抗性进化的方法将是控制疟疾的重大突破。我们认为，这可能是通过在蚊子种群中引入一种压力来实现的，这种压力可以恢复基因抗性蚊子的敏感性，并在它们不暴露于杀虫剂时减少它们的寿命。我们使用一个数学模型来表明，尽管杀虫剂施加了强烈的选择压力，适度的压力可能会使抗性的成本和收益之间的进化平衡倾向于保持敏感性。我们用感染两种耐药蚊子和一种敏感蚊子的culicvavraia微孢子虫寄生虫的实验工作表明，确实有可能以所需的方式对蚊子施加压力。感染后24 h耐药蚊的死亡率比未感染蚊高8.8倍；如果蚊子不接触杀虫剂，被微孢子虫感染的耐药蚊子的寿命大约是未感染蚊子和对杀虫剂敏感的蚊子（有或没有寄生虫）的一半。我们的研究结果表明，干扰抗性表达的生物农药或其他杀虫剂可能有助于控制疟疾控制计划中的杀虫剂抗性。
Finding a way to block the evolution insecticide resistance would be a major breakthrough for the control of malaria. We suggest that this may be possible by introducing a stress into mosquito populations that restores the sensitivity of genetically resistant mosquitoes and that decreases their longevity when they are not exposed to insecticide. We use a mathematical model to show that, despite the intense selection pressure imposed by insecticides, moderate levels of stress might tip the evolutionary balance between costs and benefits of resistance toward maintaining sensitivity. Our experimental work with the microsporidian parasite Vavraia culicis infecting two lines of resistant mosquitoes and a sensitive line suggests that it may indeed be possible to stress the mosquitoes in the required way. The mortality of resistant mosquitoes 24 h after exposure to the insecticide was up to 8.8 times higher in infected than in uninfected ones; if mosquitoes were not exposed to the insecticide, resistant mosquitoes infected by the microsporidian lived about half as long as uninfected ones and insecticide-sensitive mosquitoes (with or without the parasite). Our results suggest that biopesticides or other insecticides that interfere with the expression of resistance may help to manage insecticide resistance in programs of malaria control.
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影响因子：
2.2
作者：
CURTIS, CF;COOK, LM;WOOD, RJ
通讯作者：
WOOD, RJ
影响因子：
2.9
作者：
Fellous, Simon;Koella, Jacob C.
通讯作者：
Koella, Jacob C.
影响因子：
4.1
作者：
Koella JC;Lynch PA;Thomas MB;Read AF
通讯作者：
Read AF
DOI：
10.1098/rstb.1998.0329
发表时间：
1998-10-29
期刊：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
Curtis, CF;Miller, JE;Kasumba, I
通讯作者：
Kasumba, I
影响因子：
3.3
作者：
Agnew, P;Berticat, C;Michalakis, Y
通讯作者：
Michalakis, Y