Relationship between numerous mast cells and early follicular development in neonatal MRL/MpJ mouse ovaries.
Relationship between numerous mast cells and early follicular development in neonatal MRL/MpJ mouse ovaries.
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DOI：
10.1371/journal.pone.0077246
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Kon Y
中科院分区：
文献类型：
--
作者：
Nakamura T;Otsuka S;Ichii O;Sakata Y;Nagasaki K;Hashimoto Y;Kon Y
在新生小鼠卵巢中，称为巢的卵母细胞簇分裂成较小的囊肿，随后形成单个卵泡。在此期间，我们在MRL/MpJ小鼠卵巢中发现了大量肥大细胞，并研究了它们随卵泡发育的外观和形态。卵巢肥大细胞在出生后第0天就已经存在，倾向于定位于表面上皮附近。在11个不同的小鼠品系中，MRL/MpJ小鼠卵巢肥大细胞数量最多。卵巢肥大细胞在DBA/1、BALB/c、NZW和DBA/2小鼠中也有发现，但在C57BL/6、NZB、AKR、C3H/He、CBA和ICR小鼠中很少发现。卵巢肥大细胞表达结缔组织肥大细胞标记物，尽管MRL/MpJ小鼠表面上皮周围的肥大细胞也表达粘膜肥大细胞标记物。部分卵巢肥大细胞迁移到卵母细胞巢内，直接接触被压缩和退化的卵母细胞。MRL/MpJ小鼠巢内卵母细胞数量明显低于其他品系，卵母细胞数量与卵巢肥大细胞数量呈正相关。肥大细胞标记物的基因表达也与卵母细胞巢标记物的表达相关，这表明卵巢？肥大细胞和早期卵泡发育此外，MRL/MpJ小鼠的卵泡发育标志物的表达明显高于C57BL/6小鼠。这些结果表明卵巢肥大细胞的出现是新生MRL/MpJ小鼠的一种独特表型，卵巢肥大细胞参与了早期卵泡发育，特别是巢的破坏。
In the neonatal mouse ovary, clusters of oocytes called nests break into smaller cysts and subsequently form individual follicles. During this period, we found numerous mast cells in the ovary of MRL/MpJ mice and investigated their appearance and morphology with follicular development. The ovarian mast cells, which were already present at postnatal day 0, tended to localize adjacent to the surface epithelium. Among 11 different mouse strains, MRL/MpJ mice possessed the greatest number of ovarian mast cells. Ovarian mast cells were also found in DBA/1, BALB/c, NZW, and DBA/2 mice but rarely in C57BL/6, NZB, AKR, C3H/He, CBA, and ICR mice. The ovarian mast cells expressed connective tissue mast cell markers, although mast cells around the surface epithelium also expressed a mucosal mast cell marker in MRL/MpJ mice. Some ovarian mast cells migrated into the oocyte nests and directly contacted the compressed and degenerated oocytes. In MRL/MpJ mice, the number of oocytes in the nest was significantly lower than in the other strains, and the number of oocytes showed a positive correlation with the number of ovarian mast cells. The gene expression of a mast cell marker also correlated with the expression of an oocyte nest marker, suggesting a link between the appearance of ovarian ? 4mast cells and early follicular development. Furthermore, the expression of follicle developmental markers was significantly higher in MRL/MpJ mice than in C57BL/6 mice. These results indicate that the appearance of ovarian mast cells is a unique phenotype of neonatal MRL/MpJ mice, and that ovarian mast cells participate in early follicular development, especially nest breakdown.
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影响因子：
10.5
作者：
Coussens, LM;Raymond, WW;Hanahan, D
通讯作者：
Hanahan, D
影响因子：
3.6
作者：
BRANNSTROM, M;MAYRHOFER, G;ROBERTSON, SA
通讯作者：
ROBERTSON, SA
影响因子：
2.5
作者：
Lee, Shin-hyo;Ichii, Osamu;Kon, Yasuhiro
通讯作者：
Kon, Yasuhiro
影响因子：
6.1
作者：
De Pol, A;Vaccina, F;Marzona, L
通讯作者：
Marzona, L
影响因子：
3.6
作者：
CAVENDER, JL;MURDOCH, WJ
通讯作者：
MURDOCH, WJ