Contra-Directional Expression of Serum Homocysteine and Uric Acid as Important Biomarkers of Multiple System Atrophy Severity: A Cross-Sectional Study.
Contra-Directional Expression of Serum Homocysteine and Uric Acid as Important Biomarkers of Multiple System Atrophy Severity: A Cross-Sectional Study.
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血清同型半胱氨酸和尿酸的反向表达作为多系统萎缩严重程度的重要生物标志物：一项横断面研究。
DOI：
10.3389/fncel.2015.00247
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发表时间：
2015
影响因子：
5.3
通讯作者：
Wang Q
中科院分区：
文献类型：
--
作者：
Chen D;Wei X;Zou J;Wang R;Liu X;Xu X;Lu J;Wang Z;Tang B;Wang B;Jin K;Wang Q
与健康受试者相比，MSA患者的血清Hcy较高，尤其是男性患者。MSA患者血清UA较健康人低，尤其是男性患者。血清Hcy水平与MSA的严重程度呈显著正相关。Hcy和UA联合检测的ROC曲线显示出区分MSA与健康受试者的潜在诊断价值。有证据表明，炎症反应在多系统萎缩（MSA）的发病机制中起着关键作用。炎症介质是否可以作为可靠的生物标志物来检测MSA的严重程度和进展仍然是未知的。我们进行了一项横断面研究，包括47例MSA患者和50例年龄匹配的健康对照。检测血清同型半胱氨酸（Hcy）、尿酸（UA）、C反应蛋白（CRP）水平。这些水平与MSA的严重程度呈正相关，基于运动和非运动症状。采用统一多系统萎缩量表、帕金森病睡眠量表、非运动症状量表、Schwab & England日常生活活动量表、韦伯斯特量表、改良Hoehn-Yahr分期量表和简易精神状态检查量表对MSA的严重程度进行评定。应用受试者工作特征（ROC）曲线绘制MSA对健康受试者的诊断准确性。与健康对照组相比，MSA患者血清Hcy水平升高，UA水平降低，CRP水平无明显变化。这些发现在男性患者中尤为突出。MSA与PD患者血清Hcy、UA水平无显著性差异。有趣的是，Hcy水平与MSA严重程度（如运动功能障碍、认知能力下降和心血管症状）之间存在显著相关性。此外，同型半胱氨酸和UA的组合的ROC曲线（AUC 0.736）显示了区分MSA和健康受试者的潜在诊断价值。提示炎症介质Hcy和UA可能在MSA的发病中起重要作用。血清Hcy和UA水平的测量，然后可以是一个有用的工具，以准确区分MSA从健康受试者。
Serum Hcy was higher in MSA patients when compared to healthy subjects, particularly in male patients. Serum UA was lower in MSA patients when compared healthy subjects, particularly in male patients. Serum Hcy levels were significantly positively correlated with the severity of MSA. The ROC curve for the combination of Hcy and UA showed potential diagnostic value in discriminating MSA from healthy subjects. There is evidence suggesting that inflammatory responses play a critical role in the pathogenesis of multiple system atrophy (MSA). Whether inflammatory mediators can be used as reliable biomarkers to detect the severity and progression of MSA remains largely unknown. We performed a cross-sectional study that included 47 patients with MSA and 50 healthy age-matched controls. Serum levels of homocysteine (Hcy), uric acid (UA), and C-reactive protein (CRP) were measured. These levels positively correlated with the severity of MSA, based on both motor and non-motor symptoms. Several scales were used to rate the severity of MSA, including the Unified multiple system atrophy rating scale, Parkinson’s disease sleep scale, Non-motor Symptoms Scale, the Schwab & England activities of daily living scale, Webster Scale, modified Hoehn and Yahr staging scale, and the Mini-Mental State Examination. Receiver operating characteristic (ROC) curves was applied to map the diagnostic accuracy of MSA against healthy subjects. Compared with healthy subjects, we found that serum Hcy was higher, UA was lower, and CRP levels were unchanged in MSA patients. These findings were especially prominent in male patients. No significant differences of serum Hcy and UA were observed between patients of MSA and PD. Interestingly, there was a significant correlation between Hcy levels and MSA severity such as movement dysfunction, declined cognition, and cardiovascular symptoms. Additionally, the ROC curve for the combination of Hcy and UA (AUC 0.736) showed potential diagnostic value in discriminating MSA from healthy subjects. Our findings suggest that the inflammatory mediators Hcy and UA may play important roles in the pathogenesis of MSA. The measurement of serum Hcy and UA levels could then be a useful tool to accurately distinguish MSA from healthy subjects.
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影响因子：
3.3
作者：
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