Decaffeinated green and black tea polyphenols decrease weight gain and alter microbiome populations and function in diet-induced obese mice.
Decaffeinated green and black tea polyphenols decrease weight gain and alter microbiome populations and function in diet-induced obese mice.
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DOI：
10.1007/s00394-017-1542-8
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发表时间：
2018-12
影响因子：
5
通讯作者：
Li Z
中科院分区：
文献类型：
--
作者：
Henning SM;Yang J;Hsu M;Lee RP;Grojean EM;Ly A;Tseng CH;Heber D;Li Z
脱咖啡因的绿色茶（GT）和红茶（BT）多酚抑制喂食致肥胖饮食的小鼠的体重增加。由于肠道菌群是肥胖的重要因素，因此本研究的目的是确定肠道菌群是否在GT和BT的抗肥胖作用中发挥作用。给C57 BL/6 J小鼠喂食高脂肪/高蔗糖饮食（HF/HS，32%能量来自脂肪; 25%能量来自蔗糖）或补充有0.25%GTP或BTP的相同饮食或低脂/高蔗糖（LF/HS，10.6%能量来自脂肪，25%能量来自蔗糖）饮食4周。通过16 S rRNA基因的MiSeq测序评估细菌组成。GTP和BTP饲料导致盲肠厚壁菌门减少和拟杆菌门增加。布劳特氏菌属、Bryantella、Collinsella、乳杆菌属、Marvinbryantia、Turicibacter、Barnesiella和Parabacteroides的相对比例与茶叶提取物诱导的体重减轻显著相关。通过气相色谱分析，BTP增加了假丁酸弧菌的相对比例和肠道短链脂肪酸（SCFA）的形成。盲肠丙酸含量与假丁酸弧菌的相对比例呈显著正相关。Western blot检测显示，GTP和BTP可使肝脏5′腺苷单磷酸活化蛋白激酶（AMPK）磷酸化水平分别增加70%和289%（P < 0.05）。总之，BTP和GTP均诱导与微生物群改变和肝AMPK磷酸化增加相关的体重减轻。我们假设BTP通过增加肠道SCFA的产生增加pAMPK，而GTP通过肝脏中存在的GTP增加肝脏AMPK。
Decaffeinated green tea (GT) and black tea (BT) polyphenols inhibit weight gain in mice fed an obesogenic diet. Since the intestinal microflora is an important contributor to obesity, it was the objective of this study to determine whether the intestinal microflora plays a role in the anti-obesogenic effect of GT and BT. C57BL/6J mice were fed a high-fat/high-sucrose diet (HF/HS, 32% energy from fat; 25% energy from sucrose) or the same diet supplemented with 0.25% GTP or BTP or a low-fat/high-sucrose (LF/HS, 10.6% energy from fat, 25% energy from sucrose) diet for 4 weeks. Bacterial composition was assessed by MiSeq sequencing of the 16S rRNA gene. GTP and BTP diets resulted in a decrease of cecum Firmicutes and increase in Bacteroidetes. The relative pro-portions of Blautia, Bryantella, Collinsella, Lactobacillus, Marvinbryantia, Turicibacter, Barnesiella, and Parabacteroides were significantly correlated with weight loss induced by tea extracts. BTP increased the relative proportion of Pseudobutyrivibrio and intestinal formation of short-chain fatty acids (SCFA) analyzed by gas chromatography. Cecum propionic acid content was significantly correlated with the relative proportion of Pseudobutyrivibrio. GTP and BTP induced a significant increase in hepatic 5′adenosylmonophosphate-activated protein kinase (AMPK) phosphorylation by 70 and 289%, respectively (P < 0.05) determined by Western blot. In summary, both BTP and GTP induced weight loss in association with alteration of the microbiota and increased hepatic AMPK phosphorylation. We hypothesize that BTP increased pAMPK through increased intestinal SCFA production, while GTPs increased hepatic AMPK through GTP present in the liver.
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DOI：
10.1126/science.1241214
发表时间：
2013-09-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Ridaura VK;Faith JJ;Rey FE;Cheng J;Duncan AE;Kau AL;Griffin NW;Lombard V;Henrissat B;Bain JR;Muehlbauer MJ;Ilkayeva O;Semenkovich CF;Funai K;Hayashi DK;Lyle BJ;Martini MC;Ursell LK;Clemente JC;Van Treuren W;Walters WA;Knight R;Newgard CB;Heath AC;Gordon JI
通讯作者：
Gordon JI
影响因子：
2.6
作者：
Kasperowicz, A.;Stan-Glasek, K.;Michalowski, T.
通讯作者：
Michalowski, T.
红茶和红茶多酚对与2型糖尿病有关的α-葡萄糖苷酶和α-淀粉酶抑制的影响。
影响因子：
5
作者：
Striegel L;Kang B;Pilkenton SJ;Rychlik M;Apostolidis E
通讯作者：
Apostolidis E
补充瓜尔胶饮食的小鼠的短链脂肪酸摄取通量与代谢综合征主要生物标志物的改善相关。
影响因子：
3.7
作者：
den Besten G;Havinga R;Bleeker A;Rao S;Gerding A;van Eunen K;Groen AK;Reijngoud DJ;Bakker BM
通讯作者：
Bakker BM
影响因子：
2.6
作者：
Jin, Jong-Sik;Touyama, Mutsumi;Benno, Yoshimi
通讯作者：
Benno, Yoshimi