Relative instantaneous reproduction number of Omicron SARS-CoV-2 variant with respect to the Delta variant in Denmark.

Relative instantaneous reproduction number of Omicron SARS-CoV-2 variant with respect to the Delta variant in Denmark.
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DOI:
10.1002/jmv.27560
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发表时间:
2022-05
影响因子:
12.7
通讯作者:
--
中科院分区:
医学3区
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--
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严重急性呼吸系统综合征冠状病毒2型(SARS-CoV-2)的Omicron变异体已在世界各地迅速传播。截至2021年12月7日,丹麦共确诊758例奥密克隆病例。利用GISAID数据库中丹麦注册的Delta和Omicron变异体的核苷酸序列,我们发现在相同的流行病学条件下,Omicron的有效(瞬时)繁殖数是Delta的3.19倍(95%置信区间[CI]:2.82-3.61)。预计2021年12月28日,丹麦所有SARS-CoV-2感染者中Omicron感染的比例将超过95%,2021年12月25日至12月31日的95%CI。鉴于Delta变异或传播性低于Delta的变异在大多数国家占主导地位,一旦引入Omicron,就可能观察到病毒群体中Omicron的快速增加。准备主动控制措施是至关重要的,假设Omicron传输的实质性优势。在丹麦,Omicron相对于Delta的相对有效繁殖数估计为3.19(95%CI 2.82-3.61)。其他国家应该认识到引进Omicron会使有效繁殖数迅速增加的巨大风险。
The Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has become widespread across the world in a flashing manner. As of December 7, 2021, a total of 758 Omicron cases were confirmed in Denmark. Using the nucleotide sequences of the Delta and Omicron variants registered from Denmark in the GISAID database, we found that the effective (instantaneous) reproduction number of Omicron is 3.19 (95% confidence interval [CI]: 2.82–3.61) times greater than that of Delta under the same epidemiological conditions. The proportion of Omicron infections among all SARS‐CoV‐2 infections in Denmark was expected to exceed 95% on December 28, 2021, with a 95% CI from December 25 to December 31, 2021. Given that the Delta variant or variants less transmissible than Delta are dominant in most countries, the rapid increase in Omicron in the virus population may be observed as soon as the Omicron is introduced. Preparing proactive control measures is vital, assuming the substantial advantage of the transmission by Omicron. The relative effective reproduction number of Omicron over Delta in Denmark was estimated as 3.19 (95%CI 2.82–3.61). Other countries should recognize the substantial risk of rapid increase in the effective reproduction numbers by the introduction of Omicron.
DOI: 10.1056/nejmoa2105000
发表时间: 2021-06-10
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影响因子: --
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影响因子: --
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