Neurocognitive functioning in preschool-age children with type 1 diabetes mellitus.
Neurocognitive functioning in preschool-age children with type 1 diabetes mellitus.
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DOI：
10.1111/j.1399-5448.2009.00618.x
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发表时间：
2010-09
影响因子：
3.4
通讯作者：
Richton S
中科院分区：
文献类型：
--
作者：
Patiño-Fernández AM;Delamater AM;Applegate EB;Brady E;Eidson M;Nemery R;Gonzalez-Mendoza L;Richton S
1型糖尿病（T1DM）患儿的神经认知功能可能受损。与T1DM儿童长期神经认知功能最一致的因素是发病年龄。儿科文献表明，极端血糖可能对儿童的神经认知功能有影响，但研究结果好坏参半。本研究的目的是比较6岁前诊断为T1DM的幼儿和健康儿童（即没有慢性疾病的儿童）的神经认知功能。此外，在患有T1DM的儿童中，我们检查了他们的神经认知功能和血糖控制之间的关系。招募了68名学龄前儿童（36名患有T1DM， 32名没有慢性疾病）（M年龄= 4.4岁），并使用一系列工具来测量认知、语言和精细运动技能。患有T1DM的儿童的表现与健康对照组相似，两组的技能都在平均范围内下降。在糖尿病儿童中，血糖控制不良（HbA1c较高）与一般认知能力较低（r = - 0.44, p < 0.04）、精细运动速度较慢（r = - 0.64, p < 0.02）和接受性语言评分较低（r = - 0.39, p < 0.04）有关。这些发现表明，患有T1DM的幼儿已经表现出与慢性高血糖相关的一些负面神经认知影响。
Neurocognitive functioning may be compromised in children with type 1 diabetes mellitus (T1DM). The factor most consistently implicated in the long-term neurocognitive functioning of children with T1DM is age of onset. The pediatric literature suggests that glycemic extremes may have an effect on the neurocognitive functioning of children, but findings are mixed. The purpose of this study was to compare the neurocognitive functioning of young children with T1DM diagnosed before six years of age and healthy children (i.e., without chronic illness). Additionally, in the children with T1DM, we examined the relationship between their neurocognitive functioning and glycemic control. Sixty eight (36 with T1DM and 32 without chronic illness) preschool-age children (M age = 4.4yrs) were recruited and administered a battery of instruments to measure cognitive, language, and fine motor skills. Children with T1DM performed similarly to the healthy controls and both groups' skills fell in the average range. Among children with diabetes, poor glycemic control (higher HbA1c) was related to lower general cognitive abilities (r = -.44, p < .04), slower fine motor speed (r = -.64, p < .02), and lower receptive language scores (r = -.39, p < .04). Such findings indicate that young children with T1DM already demonstrate some negative neurocognitive effects in association with chronic hyperglycemia.
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影响因子：
2.2
作者：
Desrocher, M;Rovet, J
通讯作者：
Rovet, J
影响因子：
5.1
作者：
Strudwick, SK;Carne, C;Jones, TW
通讯作者：
Jones, TW
影响因子：
2.9
作者：
Malone, JI;Hanna, SK;Saporta, S
通讯作者：
Saporta, S
影响因子：
3.4
作者：
Perantie, Dana C.;Lim, Audrey;Hershey, Tamara
通讯作者：
Hershey, Tamara
影响因子：
168.9
作者：
Lawrie, SM;Whalley, H;Johnstone, EC
通讯作者：
Johnstone, EC