Case Report and Genomic Characterization of a Novel Porcine Nodavirus in the United States.

Case Report and Genomic Characterization of a Novel Porcine Nodavirus in the United States.
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DOI:
10.3390/v13010073
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发表时间:
2021-01-07
期刊:
Viruses
影响因子:
--
通讯作者:
Li G
Li G
中科院分区:
其他
文献类型:
--
作者:
Yang C;Wang L;Schwartz K;Burrough E;Groeltz-Thrush J;Chen Q;Zheng Y;Shen H;Li G

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诺达病毒是属于诺达病毒科的小型双节段RNA病毒。诺达病毒已在不同宿主中发现,包括昆虫、鱼、虾、虾、狗和蝙蝠。在美国,通过对具有神经症状(包括无法控制的颤抖)的猪的脑组织应用新一代测序,首次发现了一种新型猪诺达病毒。猪诺达病毒的RNA1与Flock House病毒具有最高的核苷酸同一性(51.1%),而其RNA2与犬诺达病毒(Canine nodavirus)的RNA2片段具有最高的核苷酸同一性(48%)。遗传特征将猪诺达病毒分类为甲诺达病毒属下的一个新种。需要进一步的研究来了解这种病毒的致病性和临床影响。
Nodaviruses are small bisegmented RNA viruses belonging to the family Nodaviridae. Nodaviruses have been identified in different hosts, including insects, fishes, shrimps, prawns, dogs, and bats. A novel porcine nodavirus was first identified in the United States by applying next-generation sequencing on brain tissues of pigs with neurological signs, including uncontrollable shaking. RNA1 of the porcine nodavirus had the highest nucleotide identity (51.1%) to the Flock House virus, whereas its RNA2 shared the highest nucleotide identity (48%) with the RNA2 segment of caninovirus (Canine nodavirus). Genetic characterization classified porcine nodavirus as a new species under the genus Alphanodavirus. Further studies are needed to understand the pathogenicity and clinical impacts of this virus.
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