Case Report and Genomic Characterization of a Novel Porcine Nodavirus in the United States.
Case Report and Genomic Characterization of a Novel Porcine Nodavirus in the United States.
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DOI:
10.3390/v13010073
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发表时间:
2021-01-07
期刊:
影响因子:
--
通讯作者:
Li G
中科院分区:
文献类型:
--
作者:
Yang C;Wang L;Schwartz K;Burrough E;Groeltz-Thrush J;Chen Q;Zheng Y;Shen H;Li G
Nodaviruses are small bisegmented RNA viruses belonging to the family Nodaviridae. Nodaviruses have been identified in different hosts, including insects, fishes, shrimps, prawns, dogs, and bats. A novel porcine nodavirus was first identified in the United States by applying next-generation sequencing on brain tissues of pigs with neurological signs, including uncontrollable shaking. RNA1 of the porcine nodavirus had the highest nucleotide identity (51.1%) to the Flock House virus, whereas its RNA2 shared the highest nucleotide identity (48%) with the RNA2 segment of caninovirus (Canine nodavirus). Genetic characterization classified porcine nodavirus as a new species under the genus Alphanodavirus. Further studies are needed to understand the pathogenicity and clinical impacts of this virus.
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