A New Vestibular Stimulation Mode for Motion Sickness With Emphatic Analysis of Pica.
A New Vestibular Stimulation Mode for Motion Sickness With Emphatic Analysis of Pica.
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DOI：
10.3389/fnbeh.2022.882695
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发表时间：
2022
影响因子：
3
通讯作者：
中科院分区：
文献类型：
--
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在研究工作中，啮齿类动物经常通过被动运动引起运动病（MS），这种被动运动在视觉和偶然性本体感受输入的存在下干扰前庭信号。以这种方式诱导MS会导致相互冲突的信号，这些信号激活代表多模式刺激的混合神经回路。从还原论出发，本研究中配置了一个通过前庭刺激诱发大鼠MS的实验室设置，用于MS研究，并与MS的中央前庭组成部分的因果关系相关。个体动物用定制的限制器对光不敏感，并定位在30°的倾斜度，以使耳石器官通过重力惯性矢量接收不寻常的动作。在2 h的双轴（垂直于地球）旋转（包括角加/减速）后，观察到MS的一系列特征性行为发生了显著变化，包括异食癖（吃非营养物质如高岭土）、条件性味觉回避和运动（p < 0.05）。值得注意的是，对于统计假设检验，阐述了高岭土消费的净增加量作为自变量在数据处理中的效用。此外，前庭核复合体中Fos免疫染色神经元数量明显增多，提示旋转诱导的MS与前庭激活密切相关。总之，我们的工作表明，目前的设置可以有效地引发MS通过干扰前庭信号在大鼠的背景下，良好的控制本体感觉输入和缺乏视觉传入。
Motion sickness (MS) was frequently introduced for rodents in research work through passive motion that disturbed vestibular signals in the presence of visual and aleatory, proprioceptive inputs. Inducement of MS in this way causes conflicting signals that activate intermixed neural circuits representing multimodal stimulation. From reductionism, a lab setup to elicit rat MS via vestibular stimulation was configured in the present study for MS study in connection with dissection of the central vestibular component causally underlying MS. The individual animal was blinded to light with a custom-made restrainer, and positioned at an inclination of 30° for otolith organs to receive unusual actions by gravitoinertial vector. Following a 2-h double-axis (earth–vertical) rotation involving angular acceleration/deceleration, a suit of behaviors characterizing the MS was observed to be significantly changed including pica (eating non-nutritive substance like kaolin), conditioned taste avoidance and locomotion (p < 0.05). Notably, for the statistical hypothesis testing, the utility of net increased amount of kaolin consumption as independent variables in data processing was expounded. In addition, Fos-immunostained neurons in vestibular nucleus complex were significantly increased in number, suggesting the rotation-induced MS was closely related to the vestibular activation. In conclusion, our work indicated that the present setup could effectively elicit the MS by disturbing vestibular signals in rat in the context of well-controlled proprioceptive inputs and lack of visual afference.
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影响因子：
3.3
作者：
Shimizu, N.;Wood, S.;Kushiro, K.;Yanai, S.;Perachio, A.;Makishima, T.
通讯作者：
Makishima, T.
影响因子：
7.7
作者：
Koch, Andreas;Cascorbi, Ingolf;Kuhtz-Buschbeck, Johann Peter
通讯作者：
Kuhtz-Buschbeck, Johann Peter
影响因子：
3.7
作者：
Balaban CD;Ogburn SW;Warshafsky SG;Ahmed A;Yates BJ
通讯作者：
Yates BJ
DOI：
10.1196/annals.1303.034
发表时间：
2003-01-01
期刊：
OCULOMOTOR AND VESTIBULAR SYSTEMS: THEIR FUNCTION AND DISORDERS
影响因子：
--
作者：
Cohen, B;Dai, MJ;Raphan, T
通讯作者：
Raphan, T
影响因子：
3.6
作者：
Javid, FA;Naylor, RJ
通讯作者：
Naylor, RJ