Shape information from glucose curves: functional data analysis compared with traditional summary measures.
Shape information from glucose curves: functional data analysis compared with traditional summary measures.
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DOI：
10.1186/1471-2288-13-6
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发表时间：
2013-01-17
影响因子：
4
通讯作者：
Veierød MB
中科院分区：
文献类型：
--
作者：
Frøslie KF;Røislien J;Qvigstad E;Godang K;Bollerslev J;Voldner N;Henriksen T;Veierød MB
血浆葡萄糖水平是医学护理和研究中的重要测量，并且通常通过口服葡萄糖耐量试验（OGTT）获得，在2-3小时内重复测量。通常的做法是使用OGTT曲线的简单汇总测量。然而，不同的OGTT曲线可以产生相似的汇总测量，并且生理或临床感兴趣的信息可能丢失。我们的目的是提取OGTT血糖曲线形状中固有的信息，将其与简单汇总测量的信息进行比较，并探索这些信息的临床实用性。记录了974名健康孕妇在妊娠早期两小时内的五次血糖测量的OGTT。对于每一位女性，通过功能数据分析（FDA）将五次测量转化为平滑的OGTT葡萄糖曲线，FDA是专门用于分析曲线数据的统计方法的集合。通过功能主成分分析提取OGTT血糖曲线时间变化的基本模式。将所得功能主成分（FPC）评分与常用的简单汇总指标进行比较：空腹和2小时（2 h）值、曲线下面积（AUC）和简单形状指数（2 h减去90 min值或90 min减去60 min值）。通过对妊娠后期葡萄糖耐量的回归分析，探讨FDA的临床实用性。超过99%的个别拟合曲线之间的变化表示在前三个FPC，生理学解释为“一般水平”（FPC 1），“达到峰值的时间”（FPC 2）和“振荡”（FPC 3）。FPC 1评分与AUC密切相关（r=0.999），但与其他简单汇总指标的相关性较低（-0.42 ≤r≤0.79）。FPC 2评分提供了简单汇总测量无法捕获的形状信息（−0.12≤r≤0.40）。FPC 2评分，而不是FPC 1，也不是简单的总结措施，区分妇女谁没有发展妊娠糖尿病在怀孕后期。FDA对妊娠早期OGTT血糖曲线提取了形状信息，这些信息不能通过常用的简单汇总措施识别。这一信息区分妇女和妇女之间没有妊娠糖尿病在怀孕后期。
Plasma glucose levels are important measures in medical care and research, and are often obtained from oral glucose tolerance tests (OGTT) with repeated measurements over 2–3 hours. It is common practice to use simple summary measures of OGTT curves. However, different OGTT curves can yield similar summary measures, and information of physiological or clinical interest may be lost. Our mean aim was to extract information inherent in the shape of OGTT glucose curves, compare it with the information from simple summary measures, and explore the clinical usefulness of such information. OGTTs with five glucose measurements over two hours were recorded for 974 healthy pregnant women in their first trimester. For each woman, the five measurements were transformed into smooth OGTT glucose curves by functional data analysis (FDA), a collection of statistical methods developed specifically to analyse curve data. The essential modes of temporal variation between OGTT glucose curves were extracted by functional principal component analysis. The resultant functional principal component (FPC) scores were compared with commonly used simple summary measures: fasting and two-hour (2-h) values, area under the curve (AUC) and simple shape index (2-h minus 90-min values, or 90-min minus 60-min values). Clinical usefulness of FDA was explored by regression analyses of glucose tolerance later in pregnancy. Over 99% of the variation between individually fitted curves was expressed in the first three FPCs, interpreted physiologically as “general level” (FPC1), “time to peak” (FPC2) and “oscillations” (FPC3). FPC1 scores correlated strongly with AUC (r=0.999), but less with the other simple summary measures (−0.42≤r≤0.79). FPC2 scores gave shape information not captured by simple summary measures (−0.12≤r≤0.40). FPC2 scores, but not FPC1 nor the simple summary measures, discriminated between women who did and did not develop gestational diabetes later in pregnancy. FDA of OGTT glucose curves in early pregnancy extracted shape information that was not identified by commonly used simple summary measures. This information discriminated between women with and without gestational diabetes later in pregnancy.
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影响因子：
3.7
作者：
Andersson EA;Pilgaard K;Pisinger C;Harder MN;Grarup N;Færch K;Sandholt C;Poulsen P;Witte DR;Jørgensen T;Vaag A;Pedersen O;Hansen T
通讯作者：
Hansen T
影响因子：
3.6
作者：
Nazare, Julie-Anne;de Rougemont, Alexis;Laville, Martine
通讯作者：
Laville, Martine
DOI：
10.1111/j.1532-5415.2011.03865.x
发表时间：
2012-04-01
影响因子：
6.3
作者：
Ramachandran, Ramona;Gravenstein, Kristofer S.;Chia, Chee W.
通讯作者：
Chia, Chee W.
影响因子：
2.8
作者：
Froslie, K. F.;Godang, K.;Qvigstad, E.
通讯作者：
Qvigstad, E.
影响因子：
15.9
作者：
BERGMAN, RN;PHILLIPS, LS;COBELLI, C
通讯作者：
COBELLI, C