Personal care product use as a predictor of urinary concentrations of certain phthalates, parabens, and phenols in the HERMOSA study.

Personal care product use as a predictor of urinary concentrations of certain phthalates, parabens, and phenols in the HERMOSA study.
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DOI:
10.1038/s41370-017-0003-z
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发表时间:
2019-01
影响因子:
4.5
通讯作者:
Harley KG
Harley KG
中科院分区:
医学3区
文献类型:
--
作者:
Berger KP;Kogut KR;Bradman A;She J;Gavin Q;Zahedi R;Parra KL;Harley KG

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使用个人护理产品,如化妆品、肥皂和防晒霜,可能会使青春期女孩暴露在潜在的内分泌干扰物中,包括邻苯二甲酸酯、对羟基苯甲酸酯和其他酚。我们在100名拉美裔青少年中评估了最近自我报告的个人护理产品使用与邻苯二甲酸酯、对羟基苯甲酸酯、三氯生和二苯甲酮-3(BP-3)尿代谢物浓度的关系。报告每天化妆的女孩与很少/从未使用化妆品的女孩相比,尿中邻苯二甲酸单乙酯(102.2 ng/mlvs.52.4 ng/mlP值:0.04)、对羟基苯甲酸甲酯(MP)(120.5 ng/mLvs.13.4 ng/mLP值)和对羟基苯甲酸丙酯(PP)(60.4ng/mLvs.2.9 ng/mLP值)的尿液浓度较高。报告最近使用特定化妆品的女孩,包括粉底、腮红和睫毛膏,尿中MEP、邻苯二甲酸单丁酯(MBP)、MP和PP的浓度较高。使用高露洁全牙膏与尿三氯生浓度升高86.7%相关。使用防晒霜与尿中BP-3浓度升高57.8%相关。我们的研究结果表明,个人护理产品的使用与尿液中某些邻苯二甲酸盐、对羟基苯甲酸酯和其他酚类的暴露程度较高有关。对于在重要生殖发育时期大量使用个人护理产品的青春期女孩来说,这一点可能特别相关。
Use of personal care products, such as makeup, soaps, and sunscreen, may expose adolescent girls to potential endocrine disruptors, including phthalates, parabens, and other phenols. We evaluated the relationship between recent self-reported personal care product use and concentrations for urinary metabolites of phthalates, parabens, triclosan, and benzophenone-3 (BP-3) in 100 Latina adolescents. Girls who reported using makeup every day vs. rarely/never had higher urinary concentrations of monoethyl phthalate (MEP) (102.2 ng/mL vs 52.4 ng/mL, P-value: 0.04), methyl paraben (MP) (120.5 ng/mL vs. 13.4 ng/mL, P-value <0.01), and propyl paraben (PP) (60.4 ng/mL vs. 2.9 ng/mL, P-value <0.01). Girls who reported recent use of specific makeup products, including foundation, blush, and mascara, had higher urinary concentrations of MEP, mono-n-butyl phthalate (MBP), MP, and PP. Use of Colgate Total toothpaste was associated with 86.7% higher urinary triclosan concentrations. Use of sunscreen was associated with 57.8% higher urinary concentrations of BP-3. Our findings suggest that personal care product use is associated with higher exposure to certain phthalates, parabens, and other phenols in urine. This may be especially relevant in adolescent girls who have high use of personal care products during a period of important reproductive development.
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