Different cortical involvement pattern of generalized and localized spasms: a magnetoencephalography study.
Different cortical involvement pattern of generalized and localized spasms: a magnetoencephalography study.
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DOI：
10.1016/j.yebeh.2011.08.011
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发表时间：
2011-11
期刊：
影响因子：
--
通讯作者：
Burgess RC
中科院分区：
文献类型：
--
作者：
Kakisaka Y;Gupta A;Wang ZI;Dubarry AS;Alexopoulos AV;Mosher JC;Burgess RC
我们报告成功的脑磁图（MEG）记录在一个孩子谁有广泛性癫痫痉挛（ES）以及ES仅涉及腿在记录。脑磁图源定位结果表明：1)癫痫样放电和两种ES的发作源相同，均为右侧顶叶区；2)两种ES的皮层扩散模式不同，即腿痉挛时癫痫性受累于右侧顶叶区，而全身性痉挛时癫痫性受累于快速弥漫性。本例脑磁图对两种ES的机制提供了新的见解，即两种类型的ES都是由同一个焦点产生的，在广义ES中，异常兴奋弥漫性地扩散到皮层区域。
We report successful magnetoencephalography (MEG) recording in a child who had generalized epileptic spasms (ES) as well as ES involving legs only during the recording. MEG source localization results demonstrated that 1) the origin of the interictal epileptiform discharges and of both types of ES were the same, i.e. right parietal region, and 2) the two types of ES involved different cortical spread patterns, i.e. epileptic involvement localized to right parietal region in spasms of legs, and rapid diffuse involvement in generalized spasms. The MEG in this case provided new insight about the mechanisms of the two types of ES, i.e. both were generated from the same focus and, in generalized ES, abnormal excitation spread to cortical areas diffusely.
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