Absence of association of a single-nucleotide polymorphism in the TERT-CLPTM1L locus with age-related phenotypes in a large multicohort study: the HALCyon programme.
Absence of association of a single-nucleotide polymorphism in the TERT-CLPTM1L locus with age-related phenotypes in a large multicohort study: the HALCyon programme.
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DOI：
10.1111/j.1474-9726.2011.00687.x
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发表时间：
2011-06
期刊：
影响因子：
7.8
通讯作者：
HALCyon Study Team
中科院分区：
文献类型：
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作者：
Alfred T;Ben-Shlomo Y;Cooper R;Hardy R;Cooper C;Deary IJ;Elliott J;Gunnell D;Harris SE;Kivimaki M;Kumari M;Martin RM;Power C;Sayer AA;Starr JM;Kuh D;Day IN;HALCyon Study Team
一些与年龄相关的特征与较短的端粒有关，端粒是覆盖线性染色体末端的结构。端粒维持基因TERT附近的一种常见多态性与几种癌症有关，但与其他衰老特征（如身体能力）的关系尚未报道。作为生命过程中健康老龄化（HALCyon）合作研究项目的一部分，来自9个英国队列的年龄在44岁至90岁之间的男性和女性进行了单核苷酸多态性（SNP） rs401681的基因分型。然后，我们研究了SNP与30种年龄相关表型之间的关系，包括认知和身体能力、血脂水平和肺功能，并在荟萃分析中汇集了研究内基因型效应。未发现SNP与任何认知能力测试（例如，单词回忆z-score = 0.02, 95% CI: - 0.01至0.04，p值= 0.12,n = 18 737）、体能测试（例如，握力的合并beta = - 0.02, 95% CI: - 0.045至0.006，p值= 0.14,n = 11 711）、血压、肺功能或血液测试指标之间存在显著关联。同样，在考虑认知或身体表现的后续测量时，在调整其在早期评估中的测量后，观察结果没有发现差异。在这项大型多队列研究中，SNP rs401681与广泛的年龄相关表型之间缺乏关联，这表明尽管该SNP可能与癌症有关，但它并不是其他衰老标志物的重要因素。
Several age-related traits are associated with shorter telomeres, the structures that cap the end of linear chromosomes. A common polymorphism near the telomere maintenance gene TERT has been associated with several cancers, but relationships with other aging traits such as physical capability have not been reported. As part of the Healthy Ageing across the Life Course (HALCyon) collaborative research programme, men and women aged between 44 and 90 years from nine UK cohorts were genotyped for the single-nucleotide polymorphism (SNP) rs401681. We then investigated relationships between the SNP and 30 age-related phenotypes, including cognitive and physical capability, blood lipid levels and lung function, pooling within-study genotypic effects in meta-analyses. No significant associations were found between the SNP and any of the cognitive performance tests (e.g. pooled beta per T allele for word recall z-score = 0.02, 95% CI: −0.01 to 0.04, P-value = 0.12, n = 18 737), physical performance tests (e.g. pooled beta for grip strength = −0.02, 95% CI: −0.045 to 0.006, P-value = 0.14, n = 11 711), blood pressure, lung function or blood test measures. Similarly, no differences in observations were found when considering follow-up measures of cognitive or physical performance after adjusting for its measure at an earlier assessment. The lack of associations between SNP rs401681 and a wide range of age-related phenotypes investigated in this large multicohort study suggests that while this SNP may be associated with cancer, it is not an important contributor to other markers of aging.
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影响因子：
7.8
作者：
Bakaysa, Stephanie L.;Mucci, Lorelei A.;Pedersen, Nancy L.
通讯作者：
Pedersen, Nancy L.
影响因子：
5.3
作者：
Andrew AS;Gui J;Sanderson AC;Mason RA;Morlock EV;Schned AR;Kelsey KT;Marsit CJ;Moore JH;Karagas MR
通讯作者：
Karagas MR
DOI：
10.1093/gerona/61.8.871
发表时间：
2006-08-01
影响因子：
5.1
作者：
Aviv, Abraham
通讯作者：
Aviv, Abraham
DOI：
10.1056/nejmra0903373
发表时间：
2009-12-10
期刊：
The New England journal of medicine
影响因子：
--
作者：
Calado RT;Young NS
通讯作者：
Young NS
影响因子：
30.8
作者：
通讯作者：
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