Drusenoid maculopathy in rhesus monkeys (Macaca mulatta): effects of age and gender.
Drusenoid maculopathy in rhesus monkeys (Macaca mulatta): effects of age and gender.
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DOI：
10.1007/s00417-008-0910-8
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发表时间：
2008-10
期刊：
影响因子：
--
通讯作者：
Neuringer M
中科院分区：
文献类型：
--
作者：
Gouras P;Ivert L;Landauer N;Mattison JA;Ingram DK;Neuringer M
比较猴玻璃状黄斑病变与人类年龄相关性黄斑变性，并评估年龄、性别和热量限制的影响。通过间接检眼镜检查、裂隙灯生物显微镜检查和眼底照相（包括某些情况下的荧光素血管造影）对61只雄性和60只雌性10-39岁恒河猴进行检查。其中54只猴子维持热量限制饮食（比对照水平低约30%），67只猴子维持自由饮食2-19年，所有其他环境因素保持不变。黄斑病变按5分制分级，并检查年龄、性别和饮食对患病率和严重程度的影响。对6只19-28岁黄斑玻璃疣猴的视网膜进行了组织学检查。恒河猴表现出高患病率（61%）的玻璃疣样黄斑病变。黄斑病变的患病率和严重程度随年龄增加而增加（p =0.012）。在所有10-12岁的猴子中，有整整一半的猴子有一定程度的可检测到的玻璃疣。这种在年轻成年期的高患病率表明，玻璃疣在恒河猴中比在人类中发展得早得多，人类在50-60岁时发展早期黄斑病变最快，即使在校正寿命的3倍差异时也是如此。未发现新生血管或地图样萎缩，女性患病率和严重程度高于男性（p=0.019）。热量限制的猴子在10-12岁时的患病率和严重程度略低于对照组，但差异无统计学意义。这是一个正在进行的项目，随着动物年龄的增长，热量限制组和自由组之间的差异可能会出现。一些猴子在20多岁时患上了严重的黄斑病变，而另一些猴子在30多岁时未受影响。玻璃疣的组织学与人视网膜相似。Drusenoid maculopathy是常见的恒河猴，即使在年轻的成年生活。一半的恒河猴在比人类更年轻的时候就有玻璃疣。黄斑病变的严重程度在雌性猴子中更大，在人类中并不总是发现性别差异。没有发现由于热量限制的差异，但这种干预措施的明确测试将需要更大的样本，更长的观察期，和/或更早的热量限制机构。遗传因素是隐含的，因为在相似的环境中，一些猴子在很小的时候就受到影响，而年长的猴子则没有。
To compare drusenoid maculopathy in monkeys with human age-related macular degeneration and evaluate the influence of age, gender and caloric restriction. Examination by indirect ophthalmoscopy, slit lamp biomicroscopy and fundus photography, including in some cases fluorescein angiography, was performed on 61 male and 60 female rhesus macaques of ages 10-39 years. Fifty-four of the monkeys were maintained on a calorically restricted diet (approximately 30% lower than control levels) and 67 on an approximately ad libitum diet for 2-19 years, with all other environmental factors held constant. Maculopathies were graded on a 5-point scale and the effects of age, sex, and diet on prevalence and severity were examined. The retinas of 6 monkeys with macular drusen, 19-28 years old, were examined histologically. Rhesus monkeys showed a high prevalence (61 %) of drusenoid maculopathy. The prevalence and severity of the maculopathy increased with age (p =0.012). Fully half of all monkeys aged 10-12 years had some detectable degree of drusen. This high prevalence in young adulthood indicates that drusen develop much earlier in rhesus monkeys than in humans, who develop early maculopathy most rapidly at 50-60 years of age, even when correcting for the 3-fold difference in lifespan. No neovascularization or geographic atrophy was found. Females had a higher prevalence and severity than males (p=0.019). Calorically restricted monkeys had a slightly lower prevalence and severity at 10-12 years than controls, but the difference was not statistically significant. This is an on-going project and differences between the caloric restricted and ad-lib groups may emerge as the animals age. Some monkeys developed severe maculopathy in their 20s with others unaffected in their 30s. The histology of drusen resembled those in human retina. Drusenoid maculopathy is common in rhesus monkeys even in young adult life. Half of the rhesus monkeys examined have drusen at a much younger age than in humans. Severity of maculopathy was greater in female monkeys, a gender difference not consistently found in humans. No differences were detected due to caloric restriction, but a definitive test of this intervention will require a larger sample, longer period of observation, and/or an earlier institution of caloric restriction. Genetic factors are implied because with similar environments, some monkeys are affected at an early age, while older ones are not.
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影响因子：
4.1
作者：
HOPE, GM;DAWSON, WW;SHERWOOD, MB
通讯作者：
SHERWOOD, MB
DOI：
10.1093/geronj/45.5.b148
发表时间：
1990-09-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
INGRAM, DK;CUTLER, RG;ROTH, GS
通讯作者：
ROTH, GS
影响因子：
4.8
作者：
Umeda, S;Suzuki, MT;Iwata, T
通讯作者：
Iwata, T
影响因子：
--
作者：
DASTGHEIB, K;GREEN, WR
通讯作者：
GREEN, WR
DOI：
10.1111/j.1442-9071.1980.tb01670.x
发表时间：
1980-01-01
期刊：
AUSTRALIAN JOURNAL OF OPHTHALMOLOGY
影响因子：
--
作者：
SARKS, SH
通讯作者：
SARKS, SH