Associations of adiponectin with individual European ancestry in African Americans: the Jackson Heart Study.
Associations of adiponectin with individual European ancestry in African Americans: the Jackson Heart Study.
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DOI：
10.3389/fgene.2014.00022
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发表时间：
2014
影响因子：
3.7
通讯作者：
Gibbons GH
中科院分区：
文献类型：
--
作者：
Bidulescu A;Choudhry S;Musani SK;Buxbaum SG;Liu J;Rotimi CN;Wilson JG;Taylor HA;Gibbons GH
背景：与欧洲裔美国人相比，非洲裔美国人(AAs)表现出更低的心脏代谢保护性脂联素水平，即使考虑了肥胖指标。由于很少有研究探讨再障患者脂联素和遗传混合物之间的关联，因此，在杰克逊心脏研究(JHS)这一大型社区队列中，我们使用了一组密集的祖先信息标记(AIMS)来估计AA患者的欧洲血统(PEA)个体比例。我们验证了血浆脂联素和PEA直接相关的假设，并评估了它们与一系列心脏代谢危险因素的相互作用。方法：采用双抗体夹心ELISA法检测1439例JHS患者血浆脂联素水平。使用来自HapMap Consortium的伪祖先群体基因数据，通过最大似然法，利用多达1447个全基因组预选AIMS的小组估计了PEA。采用交互作用评估、逐步线性回归和三次多变量调整回归模型分析脂联素与PEA的横截面关联性。结果：在研究参与者(62%的女性；平均年龄48±12岁)中，PEA的中位数(四分位数范围)为15.8(9.3)%。体重指数(p=0.04)和胰岛素抵抗(p=0.0001)改变了脂联素和PEA之间的联系。在非肥胖者和胰岛素敏感者(n=1141；β=0.74±0.23，p=0.001)中，脂联素与PEA直接和线性相关(β=0.62±0.28，p=0.03)，而在肥胖者和胰岛素抵抗者中则不相关。对于非肥胖参与者，没有检测到临界点效应。结论：在一个庞大的AA人群中，在非肥胖和非胰岛素抵抗参与者中，欧洲血统的个体比例与血浆脂联素呈线性和直接相关，这表明影响脂联素水平的遗传和代谢因素相互作用。
Background: Compared with European Americans, African Americans (AAs) exhibit lower levels of the cardio-metabolically protective adiponectin even after accounting for adiposity measures. Because few studies have examined in AA the association between adiponectin and genetic admixture, a dense panel of ancestry informative markers (AIMs) was used to estimate the individual proportions of European ancestry (PEA) for the AAs enrolled in a large community-based cohort, the Jackson Heart Study (JHS). We tested the hypothesis that plasma adiponectin and PEA are directly associated and assessed the interaction with a series of cardio-metabolic risk factors. Methods: Plasma specimens from 1439 JHS participants were analyzed by ELISA for adiponectin levels. Using pseudo-ancestral population genotype data from the HapMap Consortium, PEA was estimated with a panel of up to 1447 genome-wide preselected AIMs by a maximum likelihood approach. Interaction assessment, stepwise linear and cubic multivariable-adjusted regression models were used to analyze the cross-sectional association between adiponectin and PEA. Results: Among the study participants (62% women; mean age 48 ± 12 years), the median (interquartile range) of PEA was 15.8 (9.3)%. Body mass index (BMI) (p = 0.04) and insulin resistance (p = 0.0001) modified the association between adiponectin and PEA. Adiponectin was directly and linearly associated with PEA (β = 0.62 ± 0.28, p = 0.03) among non-obese (n = 673) and insulin sensitive participants (n = 1141; β = 0.74 ± 0.23, p = 0.001), but not among those obese or with insulin resistance. No threshold point effect was detected for non-obese participants. Conclusions: In a large AA population, the individual proportion of European ancestry was linearly and directly associated with plasma adiponectin among non-obese and non insulin-resistant participants, pointing to the interaction of genetic and metabolic factors influencing adiponectin levels.
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影响因子：
37.8
作者：
Go AS;Mozaffarian D;Roger VL;Benjamin EJ;Berry JD;Blaha MJ;Dai S;Ford ES;Fox CS;Franco S;Fullerton HJ;Gillespie C;Hailpern SM;Heit JA;Howard VJ;Huffman MD;Judd SE;Kissela BM;Kittner SJ;Lackland DT;Lichtman JH;Lisabeth LD;Mackey RH;Magid DJ;Marcus GM;Marelli A;Matchar DB;McGuire DK;Mohler ER 3rd;Moy CS;Mussolino ME;Neumar RW;Nichol G;Pandey DK;Paynter NP;Reeves MJ;Sorlie PD;Stein J;Towfighi A;Turan TN;Virani SS;Wong ND;Woo D;Turner MB;American Heart Association Statistics Committee and Stroke Statistics Subcommittee
通讯作者：
American Heart Association Statistics Committee and Stroke Statistics Subcommittee
影响因子：
2.7
作者：
Gayoso-Diz P;Otero-González A;Rodriguez-Alvarez MX;Gude F;García F;De Francisco A;Quintela AG
通讯作者：
Quintela AG
影响因子：
6.9
作者：
Hicks, Chindo;Zhu, Xiaofeng;Cooper, Richard S.
通讯作者：
Cooper, Richard S.
影响因子：
7.7
作者：
Duncan, BB;Schmidt, MI;Heiss, G
通讯作者：
Heiss, G
影响因子：
5.3
作者：
Fyr, Christina L. Wassel;Kanaya, Alka M.;Ziv, Elad
通讯作者：
Ziv, Elad