Dose-response: an International Journal Hormetic Modulation of Aging and Longevity by Mild Heat Stress Hormetic Modulation of Aging and Longevity by Mild Heat Stress
Dose-response: an International Journal Hormetic Modulation of Aging and Longevity by Mild Heat Stress Hormetic Modulation of Aging and Longevity by Mild Heat Stress
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剂量反应：国际期刊 轻度热应激对衰老和寿命的激素调节 轻度热应激对衰老和寿命的激素调节
DOI：
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发表时间：
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期刊：
影响因子：
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通讯作者：
Rattan
中科院分区：
文献类型：
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作者：
I. S. Suresh;Rattan
ᮀ 衰老的特点是分子损伤的随机积累、维护和修复的逐渐失败以及随之而来的与年龄相关的疾病的发生。在衰老研究和治疗中应用毒物兴奋效应是基于通过反复暴露于轻度压力来刺激维持和修复途径的原理。在一系列的实验研究中，我们表明，重复的温和热应激对体外老化的人类皮肤成纤维细胞的生长和各种其他细胞和生化特征具有抗衰老毒瘤效应。这些作用包括维持应激蛋白谱、减少氧化和糖氧化损伤蛋白的积累、刺激蛋白酶体降解异常蛋白的活性、提高细胞对乙醇、过氧化氢和紫外线 B 射线的抵抗力，以及提高各种抗氧化酶的水平。轻度热休克的抗衰老毒物兴奋效应似乎是通过激活内部抗氧化、修复和降解过程来减少蛋白质损伤和蛋白质聚集而促进的。
ᮀ Aging is characterized by a stochastic accumulation of molecular damage, progressive failure of maintenance and repair, and consequent onset of age-related diseases. Applying hormesis in aging research and therapy is based on the principle of stimulation of maintenance and repair pathways by repeated exposure to mild stress. In a series of experimental studies we have shown that repetitive mild heat stress has anti-aging hormetic effects on growth and various other cellular and biochemical characteristics of human skin fibroblasts undergoing aging in vitro. These effects include the maintenance of stress protein profiles, reduction in the accumulation of oxidatively and glycoxidatively damaged proteins, stimulation of the proteasomal activities for the degradation of abnormal proteins , improved cellular resistance to ethanol, hydrogenperoxide and ultraviolet-B rays, and enhanced levels of various antioxidant enzymes. Anti-aging hormetic effects of mild heat shock appear to be facilitated by reducing protein damage and protein aggregation by activating internal antioxidant, repair and degradation processes.
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影响因子：
2.7
作者：
King, V;Tower, J
通讯作者：
Tower, J
DOI：
10.1093/gerona/52a.1.b48
发表时间：
1997-01-01
影响因子：
5.1
作者：
Khazaeli, AA;Tatar, M;Curtsinger, JW
通讯作者：
Curtsinger, JW
DOI：
10.1073/pnas.92.16.7540
发表时间：
1995-08-01
影响因子：
11.1
作者：
LITHGOW, GJ;WHITE, TM;JOHNSON, TE
通讯作者：
JOHNSON, TE
DOI：
10.1093/gerona/57.3.b109
发表时间：
2002-03-01
影响因子：
5.1
作者：
Cypser, JR;Johnson, TE
通讯作者：
Johnson, TE
DOI：
10.1093/geronj/49.6.b270
发表时间：
1994-11-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
LITHGOW, GJ;WHITE, TM;JOHNSON, TE
通讯作者：
JOHNSON, TE