Characteristics of Streptococcus mutans genotypes and dental caries in children.
Characteristics of Streptococcus mutans genotypes and dental caries in children.
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DOI：
10.1111/eos.12044
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发表时间：
2013-06
影响因子：
1.9
通讯作者：
Childers NK
中科院分区：
文献类型：
--
作者：
Cheon K;Moser SA;Wiener HW;Whiddon J;Momeni SS;Ruby JD;Cutter GR;Childers NK
这项纵向队列研究评估了与龋齿史相关的变形链球菌基因型的多样性、共性和稳定性。67名5岁和6岁的儿童，被认为是高龋齿风险，从基线到36个月收集牙菌斑S。变异株分离和重复基因外回文PCR基因分型（共4，392株分离株）。在基线时记录每个儿童的腐烂、缺失、填充表面（dmfs/DMFS）。基线时，在911 S中发现18种不同的基因型。来自67名儿童的变异株（多样性）和13种基因型被至少2名儿童共享（共性）。每个个体的基因型数量与基线时的龋面比例（p-ds）呈正相关。在随访的39名儿童中，有24名在随访期间保持了主要基因型（稳定性），并与p-ds呈负相关。观察到的多样性，共同性和稳定性的S。变形链球菌基因型代表了该高龋风险社区的龋齿流行病学模式，这表明较少的龋面与较低的多样性和稳定性显著相关。变异基因型。
This longitudinal cohort study evaluated the diversity, commonality, and stability of Streptococcus mutans genotypes associated with dental caries history. Sixty-seven 5 and 6 yr-old children, considered being at high caries risk, had plaque collected from baseline through 36 months for S. mutans isolation and genotyping with repetitive extragenic palindromic-PCR (4,392 total isolates). Decayed, missing, filled surfaces (dmfs/DMFS) for each child were recorded at baseline. At baseline, 18 distinct genotypes were found among 911 S. mutans isolates from 67 children (diversity) and 13 genotypes were shared by at least 2 children (commonality). The number of genotypes per individual was positively associated with the proportion of decayed surfaces (p-ds) at baseline. Twenty-four of the 39 children who were available at follow-up visits maintained a predominant genotype for the follow-up periods (stability) and was negatively associated with p-ds. The observed diversity, commonality, and stability of S. mutans genotypes represent a pattern of dental caries epidemiology in this high caries risk community, which suggest fewer decayed surfaces are significantly associated with lower diversity and stability of S. mutans genotypes.
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影响因子：
9.4
作者：
Healy, M;Huong, J;Lupski, JR
通讯作者：
Lupski, JR
影响因子：
3
作者：
ALALUUSUA, S;ALALUUSUA, SJ;ASIKAINEN, S
通讯作者：
ASIKAINEN, S
影响因子：
7.6
作者：
Cheon, K.;Moser, S. A.;Childers, N. K.
通讯作者：
Childers, N. K.
影响因子：
9.4
作者：
Klein, MN;Flório, FM;Gonçalves, RB
通讯作者：
Gonçalves, RB
影响因子：
--
作者：
Ersin, NK;Kocabas, EH;Uzel, A
通讯作者：
Uzel, A