Intranasal oxytocin modulates neural functional connectivity during human social interaction.
Intranasal oxytocin modulates neural functional connectivity during human social interaction.
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DOI：
10.1002/ajp.22740
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发表时间：
2018-10
影响因子：
2.4
通讯作者：
Haroon E
中科院分区：
文献类型：
--
作者：
Rilling JK;Chen X;Chen X;Haroon E
催产素(OT)调节灵长类和许多其他脊椎动物的社会行为。对非灵长类动物的研究表明，OT除了影响单个大脑区域的活动外，还影响涉及社会行为的区域网络的功能连接。在此之前，我们使用fMRI对受试者在鼻内注射催产素(Inot)或安慰剂后的二元社交任务中的脑功能进行成像，并使用标准的一般线性模型分析数据。在这里，我们对这些数据进行广泛的重新分析，以探索OT如何调节动物研究涉及的社会行为中的神经网络的功能连接。催产素引起男性积极社会互动时功能连通性的普遍增加，以及女性消极社会互动时功能连通性的普遍下降。Meynert基底核是选择性注意和动机的重要调节者，其OT受体密度特别高，具有最多数量的OT调节连接。已知的接受中脑边缘多巴胺投射的区域，如伏隔核和外侧隔，也是OT对功能连接的影响的枢纽。我们的结果表明，OT影响灵长类社会认知的神经机制可能包括调节其他动物社会行为的神经网络活动模式的变化。
Oxytocin (OT) modulates social behavior in primates and many other vertebrate species. Studies in non-primate animals have demonstrated that, in addition to influencing activity within individual brain areas, OT influences functional connectivity across networks of areas involved in social behavior. Previously, we used fMRI to image brain function in human subjects during a dyadic social interaction task following administration of either intranasal oxytocin (INOT) or placebo, and analyzed the data with a standard general linear model. Here, we conduct an extensive re-analysis of these data to explore how OT modulates functional connectivity across a neural network that animal studies implicate in social behavior. OT induced widespread increases in functional connectivity in response to positive social interactions among men and widespread decreases in functional connectivity in response to negative social interactions among women. Nucleus basalis of Meynert, an important regulator of selective attention and motivation with a particularly high density of OT receptors, had the largest number of OT-modulated connections. Regions known to receive mesolimbic dopamine projections such as the nucleus accumbens and lateral septum were also hubs for OT effects on functional connectivity. Our results suggest that the neural mechanism by which OT influences primate social cognition may include changes in patterns of activity across neural networks that regulate social behavior in other animals.
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