Pesticide and Surfactant Mixtures Alter Sexual Differentiation in Japanese Medaka (Oryzias latipes)
Pesticide and Surfactant Mixtures Alter Sexual Differentiation in Japanese Medaka (Oryzias latipes)
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农药和表面活性剂混合物改变日本青鳉（Oryzias latipes）的性别分化
DOI：
10.1021/acsestwater.1c00094
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Daniel Schlenk
中科院分区：
文献类型：
--
作者：
Shuying Li;Tiantian Hu;Luísa Becker Bertotto;Yao Jiang;Wenjun Gui;Daniel Schlenk
从弗朗西斯科湾三角洲的加州使用雌激素活性的水提取物的直接分析表明，农药，联苯菊酯，敌草隆，以及烷基酚表面活性剂，观察到的活性馏分。为了确定混合物的雌激素活性是否对性发育有任何影响，将日本青鳉（Oryzias latipes）胚胎暴露于环境浓度的化合物，单独和作为混合物，使用美国环境保护署（USEPA），内分泌干扰物筛选计划和经济合作与发展组织（OECD）分析的组件。敌草隆和表面活性剂单独处理的青鳉，表型雌虫比例分别为88.9 ± 19.2%和66.4 ± 3.8%。当敌草隆与表面活性剂组合时，93.3 ± 5.8%的动物是雌性。为了评价表型雌性动物是否从遗传学雄性动物改变，在处理后测量动物中雄性特异性基因（DMY）的表达。用环境浓度的表面活性剂和敌草隆处理的动物具有较高百分比（78 ± 19%）的来自基因型雄性的表型雌性。我们的研究结果表明，农药和表面活性剂的混合物可能会改变鱼类胚胎暴露后的性发育。
Effects-directed analyses of water extracts from the San Francisco Bay Delta of California using estrogenic activity indicated that the pesticides, bifenthrin, and diuron, as well as alkylphenol surfactants, were observed in active fractions. To determine whether the estrogenic activity of the mixture had any impacts on sexual development, Japanese medaka (Oryzias latipes) embryos were exposed to an ambient concentration of the compounds, individually and as mixtures, using components of the US Environmental Protection Agency (USEPA), Endocrine Disruptor Screening Program, and Organisation for Economic Co-operation and Development (OECD) assay. In medaka exposed to diuron, or surfactants alone, the percentages of phenotypic females were 88.9 ± 19.2% and 66.4 ± 3.8%, respectively. When diuron was combined with surfactants, 93.3 ± 5.8% of the animals were female. To evaluate whether phenotypic females were changed from genetically male animals, the expression of the male-specific gene (DMY) was measured in animals following treatment. Treatments with ambient concentrations of surfactants and diuron had animals with higher percentages (78 ± 19%) of phenotypic females that were derived from genotypic males. Our results demonstrated that mixtures of pesticides and surfactants may alter sexual development after embryonic exposure in fish.
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影响因子：
2.5
作者：
J. Koslow;E. Miller;J. Mcgowan
通讯作者：
J. Koslow;E. Miller;J. Mcgowan
p,p '-DDE 在环境相关浓度下诱导日本青鳉 (Oryzias latipes) 的性腺双性：与 o,p '-DDT 的比较
影响因子：
11.4
作者：
Sun Jianxian;Wang Chen;Peng Hui;Zheng Guomao;Zhang Shiyi;Hu Jianying;Hu JY
通讯作者：
Hu JY
影响因子：
6.8
作者：
Susanne Knörr;T. Braunbeck
通讯作者：
Susanne Knörr;T. Braunbeck
DOI：
10.1007/s00244-014-0098-3
发表时间：
2015-02
影响因子：
4
作者：
J. Crago;K. Tran;A. Budicin;B. Schreiber;Ramon Lavado;Daniel Schlenk
通讯作者：
J. Crago;K. Tran;A. Budicin;B. Schreiber;Ramon Lavado;Daniel Schlenk
影响因子：
2.7
作者：
Garcia, Carlos Eduardo de O.;Araujo, Bruno C.;Moreira, Renata Guimaraes
通讯作者：
Moreira, Renata Guimaraes