Laminar-dependent effects of cortical state on auditory cortical spontaneous activity.
Laminar-dependent effects of cortical state on auditory cortical spontaneous activity.
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DOI：
10.3389/fncir.2012.00109
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发表时间：
2012
影响因子：
3.5
通讯作者：
Harris KD
中科院分区：
文献类型：
--
作者：
Sakata S;Harris KD
即使在没有外部输入的情况下，皮层回路也会自发地产生协调活动。这种活动的特点取决于皮质状态。我们研究了状态如何影响组织的自发活动在体内大鼠听觉皮层层，使用形态学识别的神经元和大规模的电生理记录的aptacellular记录。表层锥体细胞（PC）和假定的快速尖峰的中间神经元（FS）的皮质deserminization过程中始终受到抑制。深层的PC表现出异质性的反应，去铁化，与一些细胞表现出增加的速率，通常是大簇状PC的高基线放电率，但不是FS。一致的结果之间发现自发发生在未麻醉的动物，和电刺激的脚桥被盖（PPT）核乌拉坦麻醉下诱发的去神经元化。我们推测，减少浅层放电可能会增强大脑从嘈杂的大脑活动中提取行为相关信号。
Cortical circuits spontaneously generate coordinated activity even in the absence of external inputs. The character of this activity depends on cortical state. We investigated how state affects the organization of spontaneous activity across layers of rat auditory cortex in vivo, using juxtacellular recording of morphologically identified neurons and large-scale electrophysiological recordings. Superficial pyramidal cells (PCs) and putative fast-spiking interneurons (FSs) were consistently suppressed during cortical desynchronization. PCs in deep layers showed heterogeneous responses to desynchronization, with some cells showing increased rates, typically large tufted PCs of high baseline firing rate, but not FSs. Consistent results were found between desynchronization occurring spontaneously in unanesthetized animals, and desynchronization evoked by electrical stimulation of the pedunculopontine tegmental (PPT) nucleus under urethane anesthesia. We hypothesize that reduction in superficial layer firing may enhance the brain's extraction of behaviorally relevant signals from noisy brain activity.
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影响因子：
56.9
作者：
HUBEL, DH;HENSON, CO;GALAMBOS, R
通讯作者：
GALAMBOS, R
影响因子：
15.9
作者：
Destexhe, Alain;Hughes, Stuart W.;Rudolph, Michelle;Crunelli, Vincenzo
通讯作者：
Crunelli, Vincenzo
影响因子：
34.7
作者：
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通讯作者：
Thiele, Alexander
影响因子：
16.2
作者：
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通讯作者：
McCormick, David A.
DOI：
10.1073/pnas.0904143106
发表时间：
2009-09-22
影响因子：
11.1
作者：
de Kock, Christiaan P. J.;Sakmann, Bert
通讯作者：
Sakmann, Bert