Increased fMRI activity correlations in autobiographical memory versus resting states.
Increased fMRI activity correlations in autobiographical memory versus resting states.
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DOI：
10.1002/hbm.24248
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发表时间：
2018-11
影响因子：
4.8
通讯作者：
Voss JL
中科院分区：
文献类型：
--
作者：
Warren KN;Hermiller MS;Nilakantan AS;O'Neil J;Palumbo RT;Voss JL
Autobiographical memory occurs when individuals retrieve personal experiences and has been associated with fMRI activity of a distributed brain network including medial-prefrontal, posterior-cingulate, and temporo-parietal cortex and the hippocampus. Although this network is typically defined via activity evoked by specific autobiographical retrieval prompts, it has high similarity to the default-mode network (DMN) identified during the resting state via analysis of activity correlations. We sought to determine whether activity correlation analysis could be used to identify the autobiographical network during extended bouts of retrieval, relative to a closely matched resting-state scan with no explicit autobiographical demands. Whole-brain, global-correlativity analysis of data from 22 participants was used to identify regions with activity correlation differences between autobiographical retrieval and resting states. Increased correlations were identified for retrieval versus resting states within a distributed network that included most of the regions prototypical for autobiographical memory. Further, this distributed network segregated based on hierarchical clustering into two subnetworks comprised of regions related to memory and cognitive control, suggesting greater functional segregation of these subnetworks during autobiographical memory than during rest. DMN regions were important drivers of these effects, with increased correlations between DMN and non-DMN regions for the retrieval state and segregation of the DMN into distinct subnetworks during the retrieval state only. These findings indicate that the autobiographical network can be robustly identified via activity correlation analysis during relatively unconstrained periods of autobiographical retrieval, and that retrieval leads to functional organization of DMN and non-DMN regions different to that observed during the resting state.
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