Adaptive and nonadaptive responses to voluntary wheel running by mdx mice.
Adaptive and nonadaptive responses to voluntary wheel running by mdx mice.
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DOI：
10.1002/mus.21141
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发表时间：
2008-10
期刊：
影响因子：
3.4
通讯作者：
Lowe, Dawn A.
中科院分区：
文献类型：
--
作者：
Landisch, Rachel M.;Kosir, Allison M.;Nelson, Steven A.;Baltgalvis, Kristen A.;Lowe, Dawn A.
本研究的目的是确定mdx小鼠后肢肌肉适应自主耐力运动的程度。mdx和C57BL小鼠进行8周的轮跑或维持正常的笼活动。mdx小鼠的有益适应包括肌肉质量、纤维大小和基于肌球蛋白重链（MHC）异构体表达的纤维类型的变化。这些适应的发生没有增加纤维中心核和胚胎MHC表达。然而，一个不希望的结果是，mdx小鼠的肌肉线粒体酶活性并没有像C57BL小鼠那样随着运动而改善。运动后营养不良肌肉的细胞重塑尚未得到充分的研究。在这项研究中，我们发现mdx小鼠肌肉中出现了一些（但不是全部）预期的适应性。我们必须更好地了解这些（非）适应性，以便告知DMD患者运动的好处。
The purpose of this study was to determine the extent to which hindlimb muscles of mdx mice adapt to a voluntary endurance type of exercise. mdx and C57BL mice engaged in 8 weeks of wheel running or maintained normal cage activities. Beneficial adaptations that occurred in mdx mice included changes in muscle mass, fiber size, and fiber types based on myosin heavy chain (MHC) isoform expression. These adaptations occurred without increases in fiber central nuclei and embryonic MHC expression. An undesirable outcome, however, was that muscle mitochondrial enzyme activities did not improve with exercise in mdx mice as they did in C57BL mice. Cellular remodeling of dystrophic muscle following exercise has not been studied adequately. In this study we found that some, but not all, of the expected adaptations occurred in mdx mouse muscle. We must better understand these (non)adaptations in order to inform individuals with DMD about the benefits of exercise.
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DOI：
10.1249/01.mss.0000183179.86594.4f
发表时间：
2006-02-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Davidson, SR;Burnett, M;Hoffman-Goetz, L
通讯作者：
Hoffman-Goetz, L
影响因子：
2.7
作者：
ANDERSON, JE;BRESSLER, BH;OVALLE, WK
通讯作者：
OVALLE, WK
DOI：
10.1249/01.mss.0000241649.15006.b8
发表时间：
2007-02-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Gorzek, Jeffrey F.;Hendrickson, Kaysie C.;Lowe, Dawn A.
通讯作者：
Lowe, Dawn A.
DOI：
10.1111/j.1475-097x.1982.tb00001.x
发表时间：
1982-01-01
期刊：
CLINICAL PHYSIOLOGY
影响因子：
--
作者：
GOLLNICK, PD;SALTIN, B
通讯作者：
SALTIN, B
DOI：
10.1098/rspb.1993.0077
发表时间：
1993-07-22
影响因子：
4.7
作者：
HAYES, A;LYNCH, GS;WILLIAMS, DA
通讯作者：
WILLIAMS, DA