Potential of adipose-derived stem cells for treatment of erectile dysfunction.
Potential of adipose-derived stem cells for treatment of erectile dysfunction.
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DOI：
10.1111/j.1743-6109.2008.01190.x
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发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Lue TF
中科院分区：
文献类型：
--
作者：
Lin G;Banie L;Ning H;Bella AJ;Lin CS;Lue TF
脂肪干细胞是存在于脂肪组织中的一种体细胞，具有自我更新、分化为一种或多种表型和功能再生受损组织的能力，通过干细胞治疗有助于勃起功能的恢复。综述有关脂肪干细胞的可获得性、分化为功能细胞以及这些细胞治疗勃起功能障碍(ED)的潜力的现有证据。我们研究了目前与脂肪干细胞的定义和特征相关的数据，包括这些细胞的分化以及脂肪干细胞治疗在勃起功能障碍大鼠模型中的初步效果。有强有力的证据支持ADSCs是治疗勃起功能障碍的潜在干细胞治疗来源的概念。脂肪来源的干细胞分布在脂肪组织的血管旁。在特定的诱导条件下，这些细胞在体外分化为神经元样细胞、平滑肌细胞和内皮细胞。胰岛素样生长因子/胰岛素样生长因子受体(IGF/IGFR)通路参与神经元分化，成纤维细胞生长因子2(FGF2)通路参与内皮分化。此外，内部核糖体进入位点(IRES)调控的基因翻译与这些类型的分化有关。在初步的体内实验中，脂肪来源的干细胞功能恢复了受损的勃起功能。因此，需要进一步研究其内在机制。脂肪来源的干细胞是治疗勃起功能障碍的潜在干细胞来源，这突显了在不久的将来对勃起功能障碍进行有效的临床治疗的可能性。
Adipose derived stem cells (ADSCs) are a somatic stem cell population contained in fat tissue that possess the ability for self-renewal, differentiation into one or more phenotypes and functional regeneration of damaged tissue, which will benefit the recovery of erectile function by using a stem cell based therapy. To review available evidence concerning adipose derived stem cell availability, differentiation into functional cells, and the potential of these cells for the treatment of erectile dysfunction (ED). We examined the current data associated with the definition and characterization of adipose derived stem cells, including the differentiation of these cells and the initial effects of adipose derived stem cell therapy in a rat model of erectile dysfunction. There is strong evidence supporting the concept that ADSCs are a potential stem cell therapy source for treatment of erectile dysfunction. The adipose derived stem cells are paravascularly localized in the adipose tissue. Under specific induction medium conditions, these cells differentiated into neuron-like cells, smooth muscle cells and endothelium in vitro. The insulin-like growth factor/insulin-like growth factor receptor (IGF/IGFR) pathway participates in neuronal differentiation while the fibroblast growth factor 2 (FGF2) pathway is involved in endothelium differentiation. In addition, the internal ribosomal entry sites (IRES) regulated gene translation is related to these types of differentiation. In a preliminary in-vivo experiment, the adipose derived stem cells functionally recovered the damaged erectile function. Therefore, the underlying mechanism needs be further examined. The adipose derived stem cells are a potential source of stem cells for treatment of erectile dysfunction, which highlights the possibility of an effective clinical therapy for ED in the near future.
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DOI：
10.1016/j.bbrc.2007.05.070
发表时间：
2007-07-27
影响因子：
3.1
作者：
Kakudo, Natsuko;Shimotsuma, Ayuko;Kusumoto, Kenji
通讯作者：
Kusumoto, Kenji
影响因子：
3.5
作者：
Bella, Anthony J.;Hayashi, Narihiko;Lue, Tom F.
通讯作者：
Lue, Tom F.
影响因子：
3.1
作者：
Lendeckel, S;Jödicke, A;Howaldt, HP
通讯作者：
Howaldt, HP
影响因子：
2.9
作者：
Ning, Hongxiu;Lin, Guiting;Lin, Ching-Shwun
通讯作者：
Lin, Ching-Shwun
影响因子：
4
作者：
Lin G;Garcia M;Ning H;Banie L;Guo YL;Lue TF;Lin CS
通讯作者：
Lin CS