Genome Sequences of Akhmeta Virus, an Early Divergent Old World Orthopoxvirus.
Genome Sequences of Akhmeta Virus, an Early Divergent Old World Orthopoxvirus.
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DOI：
10.3390/v10050252
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发表时间：
2018-05-12
期刊：
影响因子：
--
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Gao J;Gigante C;Khmaladze E;Liu P;Tang S;Wilkins K;Zhao K;Davidson W;Nakazawa Y;Maghlakelidze G;Geleishvili M;Kokhreidze M;Carroll DS;Emerson G;Li Y
对从格鲁吉亚Akhmeta和Vani地区分离的正痘病毒新种Akhmeta病毒(AKMV)的三个分离株的全基因组序列进行了注释和讨论。AKMV基因组在基因组内容和结构上与牛痘病毒(CPXV)相似，但AKMV与东半球OPXV之间的序列同源性低于东半球OPXV的其他已知物种。系统发育分析表明，AKMV的分化早于其他东半球OPXV。AKMV分离物在OPXV系统发育中形成了一个单系分支，但AKMV分离物之间的序列变异高于刚果盆地和西非猴痘病毒株之间的序列变异。来自Vani的一个AKMV分离物在左侧末端含有大约6kb的序列，与CPXV的相似性比其他AKMV分离物高，而基因组的其余部分与AKMV最相似，这表明AKMV和CPXV在一个包含多个寄主范围和毒力基因的区域进行了重组。
Annotated whole genome sequences of three isolates of the Akhmeta virus (AKMV), a novel species of orthopoxvirus (OPXV), isolated from the Akhmeta and Vani regions of the country Georgia, are presented and discussed. The AKMV genome is similar in genomic content and structure to that of the cowpox virus (CPXV), but a lower sequence identity was found between AKMV and Old World OPXVs than between other known species of Old World OPXVs. Phylogenetic analysis showed that AKMV diverged prior to other Old World OPXV. AKMV isolates formed a monophyletic clade in the OPXV phylogeny, yet the sequence variability between AKMV isolates was higher than between the monkeypox virus strains in the Congo basin and West Africa. An AKMV isolate from Vani contained approximately six kb sequence in the left terminal region that shared a higher similarity with CPXV than with other AKMV isolates, whereas the rest of the genome was most similar to AKMV, suggesting recombination between AKMV and CPXV in a region containing several host range and virulence genes.
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影响因子：
2.1
作者：
Khalafalla, Abdelmalik I.;Abdelazim, Fatima
通讯作者：
Abdelazim, Fatima
影响因子：
10.7
作者：
Katoh K;Standley DM
通讯作者：
Standley DM
影响因子：
3.7
作者：
Dabrowski PW;Radonić A;Kurth A;Nitsche A
通讯作者：
Nitsche A
DOI：
10.1093/bioinformatics/bts199
发表时间：
2012-06-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Kearse M;Moir R;Wilson A;Stones-Havas S;Cheung M;Sturrock S;Buxton S;Cooper A;Markowitz S;Duran C;Thierer T;Ashton B;Meintjes P;Drummond A
通讯作者：
Drummond A
影响因子：
3.7
作者：
GOEBEL, SJ;JOHNSON, GP;PAOLETTI, E
通讯作者：
PAOLETTI, E