The role of the tumor microbe microenvironment in the tumor immune microenvironment: bystander, activator, or inhibitor?
The role of the tumor microbe microenvironment in the tumor immune microenvironment: bystander, activator, or inhibitor?
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肿瘤微生物微环境在肿瘤免疫微环境中的作用：旁观者、激活剂还是抑制剂？
DOI：
10.1186/s13046-021-02128-w
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发表时间：
2021-10-16
期刊：
影响因子：
--
通讯作者：
Shen H
中科院分区：
文献类型：
--
作者：
Ma J;Huang L;Hu D;Zeng S;Han Y;Shen H
癌症免疫治疗的疗效很大程度上取决于肿瘤微环境，尤其是肿瘤免疫微环境。新兴研究声称微生物存在于肿瘤细胞和免疫细胞内，表明这些微生物可以影响肿瘤免疫微环境的状态。这篇综述首次描述了肿瘤内微生物及其产物的概况，本文定义为肿瘤微生物微环境。肿瘤微生物微环境在肿瘤免疫微环境中的作用是多方面的：要么作为免疫激活剂、抑制剂，要么作为旁观者。潜在机制包括：（I）癌细胞和免疫细胞呈递微生物抗原，（II）与肿瘤抗原共享的微生物抗原拟态，（III）微生物诱导的免疫原性细胞死亡，（IV）模式识别受体介导的微生物佐剂性，（V）微生物衍生的代谢物，以及（VI）抑制性检查点的微生物刺激。该综述进一步建议使用肿瘤微生物微环境的潜在调节策略来增强检查点抑制剂的疗效并减少副作用。最后，回顾强调了该领域有待回答的一些关键问题，并提供了可能的解决方案。总体而言，肿瘤微生物微环境调节肿瘤免疫微环境，使其成为改善免疫治疗的潜在靶点。这是一个面临重大挑战的新领域，值得进一步探索。
The efficacy of cancer immunotherapy largely depends on the tumor microenvironment, especially the tumor immune microenvironment. Emerging studies have claimed that microbes reside within tumor cells and immune cells, suggesting that these microbes can impact the state of the tumor immune microenvironment. For the first time, this review delineates the landscape of intra-tumoral microbes and their products, herein defined as the tumor microbe microenvironment. The role of the tumor microbe microenvironment in the tumor immune microenvironment is multifaceted: either as an immune activator, inhibitor, or bystander. The underlying mechanisms include: (I) the presentation of microbial antigens by cancer cells and immune cells, (II) microbial antigens mimicry shared with tumor antigens, (III) microbe-induced immunogenic cell death, (IV) microbial adjuvanticity mediated by pattern recognition receptors, (V) microbe-derived metabolites, and (VI) microbial stimulation of inhibitory checkpoints. The review further suggests the use of potential modulation strategies of the tumor microbe microenvironment to enhance the efficacy and reduce the adverse effects of checkpoint inhibitors. Lastly, the review highlights some critical questions awaiting to be answered in this field and provides possible solutions. Overall, the tumor microbe microenvironment modulates the tumor immune microenvironment, making it a potential target for improving immunotherapy. It is a novel field facing major challenges and deserves further exploration.
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影响因子：
--
作者：
Booth L;Roberts JL;Poklepovic A;Kirkwood J;Dent P
通讯作者：
Dent P
DOI：
10.3322/caac.21398
发表时间：
2017-07-08
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Bhatt AP;Redinbo MR;Bultman SJ
通讯作者：
Bultman SJ
影响因子：
11.5
作者：
Bonnet, Mathilde;Buc, Emmanuel;Darfeuille-Michaud, Arlette
通讯作者：
Darfeuille-Michaud, Arlette
影响因子：
82.9
作者：
Binnewies M;Roberts EW;Kersten K;Chan V;Fearon DF;Merad M;Coussens LM;Gabrilovich DI;Ostrand-Rosenberg S;Hedrick CC;Vonderheide RH;Pittet MJ;Jain RK;Zou W;Howcroft TK;Woodhouse EC;Weinberg RA;Krummel MF
通讯作者：
Krummel MF
手术中的细菌和真菌菌群去除肺癌样品。
影响因子：
1.6
作者：
Apostolou P;Tsantsaridou A;Papasotiriou I;Toloudi M;Chatziioannou M;Giamouzis G
通讯作者：
Giamouzis G