Abnormal Spontaneous Brain Activity in Early Parkinson's Disease With Mild Cognitive Impairment: A Resting-State fMRI Study.
Abnormal Spontaneous Brain Activity in Early Parkinson's Disease With Mild Cognitive Impairment: A Resting-State fMRI Study.
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伴有轻度认知障碍的早期帕金森病的异常自发大脑活动：静息态功能磁共振成像研究
DOI：
10.3389/fphys.2018.01093
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发表时间：
2018
影响因子：
4
通讯作者：
Wang H
中科院分区：
文献类型：
--
作者：
Wang Z;Jia X;Chen H;Feng T;Wang H
轻度认知障碍（MCI）是早期帕金森病（PD）诊断时常见的基线症状，但其神经机制尚不清楚。为了解决这一问题，本研究采用了19例drug-naïve认知正常PD患者（PD- nc）、10例PD合并MCI （PD-MCI）和13例年龄和性别匹配的健康对照（HC）的静息状态功能磁共振成像数据，这些数据来自帕金森进展标志物计划（PPMI） （http://www.ppmi-info.org/），并检查了PD-MCI中的异常自发脑活动。通过检测血氧水平依赖性信号的低频波动幅度（ALFF）来测量自发性脑活动的模式。在一般线性模型下，以年龄、性别和数据中心为附加协变量，在非参数排列检验下，对三组患者进行体素单向协方差分析和ALFF事后分析。事后分析中的统计显著性通过小体积校正校正，聚类水平阈值p < 0.05 （n = 10000个排列，fwe校正）。PD-MCI组的临床和神经心理学评估[即统一帕金森病评定量表（UPDRS）总分、蒙特利尔认知评估（MoCA）和认知领域]与区域ALFF的相关性。与HC相比，两组PD均表现出枕区ALFF减少（Calcarine_R/Cuneus_R）。PD-MCI组在右侧额下回（Frontal_Inf_Oper_R）眼区ALFF增加。与PD-NC相比，PD-MCI组Frontal_Inf_Oper_R和左侧梭状回ALFF显著升高（ps < 0.05）。相关分析显示，Frontal_Inf_Oper_R中的ALFF与UPDRS总分呈正相关（p < 0.05），与MoCA评分呈微负相关。在认知领域，该区域的ALFF与SF测验得分呈显著负相关（p < 0.01），与符号数字模态测验得分呈微负相关（p < 0.01）。总之，我们得出结论，早期PD伴MCI的右侧额下回过度活跃，提示认知能力下降时代偿性招募，这可能为PD的痴呆进展和潜在的综合治疗提供思路。
Mild cognitive impairment (MCI) is a common symptom at the baseline of early Parkinson’s disease (PD) diagnosis, but the neural mechanism is unclear. To address the issue, the present study employed resting-state functional magnetic resonance imaging data of 19 drug-naïve PD patients with normal cognition (PD-NC), 10 PD patients with MCI (PD-MCI) and 13 age- and gender-matched healthy controls (HC) from the Parkinson’s progression markers initiative (PPMI) (http://www.ppmi-info.org/), and examined abnormal spontaneous brain activities in the PD-MCI. The pattern of spontaneous brain activity was measured by examining the amplitude of low-frequency fluctuations (ALFF) of blood oxygen level dependent signal. Voxel-wise one-way analysis of covariance and post hoc analyses of ALFF were performed under non-parametric permutation tests in a general linear model among the three groups, with age, gender and data center as additional covariates. Statistical significances in the post hoc analysis were corrected by a small volume correction with a cluster-level threshold of p < 0.05 (n = 10000 permutations, FWE-corrected). Correlations of clinical and neuropsychological assessments [i.e., Unified Parkinson’s Disease Rating Scale (UPDRS) total score, Montreal Cognitive Assessment (MoCA) and cognitive domains] with the regional ALFF were performed in the PD-MCI group. Compared with the HC, both PD groups exhibited reduced ALFF in the occipital area (Calcarine_R/Cuneus_R). Specially, the PD-MCI group additionally exhibited increased ALFF in the opercular part of right inferior frontal gyrus (Frontal_Inf_Oper_R). Comparing with the PD-NC, the PD-MCI group exhibited significantly higher ALFF in the Frontal_Inf_Oper_R and left fusiform gyus (ps < 0.05). The correlation analysis revealed that the ALFF in the Frontal_Inf_Oper_R was positively correlated with the UPDRS total score (p < 0.05), but marginally negatively correlated with the MoCA score. For cognitive domains, the ALFF in the region also showed a significantly negative correlation with the score of SF test (p < 0.01) and a marginally negative correlation with the score of Symbol-Digit Modalities Test. Together, we concluded hyperactivity in the right inferior frontal gyrus in early PD with MCI, suggesting a compensatory recruitment in response to cognitive decline, which may shed light on thought of dementia progression and potentially comprehensive treatment in PD.
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影响因子：
4.3
作者：
Ekman U;Eriksson J;Forsgren L;Domellöf ME;Elgh E;Lundquist A;Nyberg L
通讯作者：
Nyberg L
影响因子：
9.9
作者：
Dalrymple-Alford, J. C.;MacAskill, M. R.;Anderson, T. J.
通讯作者：
Anderson, T. J.
影响因子：
2.6
作者：
Garcia-Ptacek, Sara;Kramberger, Milica G.
通讯作者：
Kramberger, Milica G.
影响因子：
3.7
作者：
Köhler, S;McIntosh, AR;Winocur, G
通讯作者：
Winocur, G
患有轻度认知障碍的初治帕金森病的默认模式网络功能障碍：一项静息态功能磁共振成像研究
影响因子：
4.8
作者：
Hou Y;Yang J;Luo C;Song W;Ou R;Liu W;Gong Q;Shang H
通讯作者：
Shang H