Neural mechanisms supporting the relationship between dispositional mindfulness and pain.
Neural mechanisms supporting the relationship between dispositional mindfulness and pain.
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DOI：
10.1097/j.pain.0000000000001344
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发表时间：
2018-12
期刊：
影响因子：
7.4
通讯作者：
Coghill RC
中科院分区：
文献类型：
--
作者：
Zeidan F;Salomons T;Farris SR;Emerson NM;Adler-Neal A;Jung Y;Coghill RC
疼痛敏感性的个体间差异是感觉、认知情感和性格因素之间相互作用的函数。特质正念（Trait mindfulness）的特征是非反应性地维持对当前时刻的注意力的先天能力，是一种与较低的临床疼痛结果相关的心理结构。然而，支持气质正念的神经机制是未知的。在一项比较正念和安慰剂镇痛的研究中获得的探索性数据分析中，我们试图确定气质正念是否与较低的疼痛敏感性相关。我们还旨在确定支持特质正念与伤害性刺激引起的疼痛之间假设的反向关系的大脑机制。我们假设特质正念与较低的疼痛和默认模式网络的更大失活有关。76名健康志愿者完成了弗赖堡正念量表（FMI），并在基于灌注的功能磁共振成像期间接受了无害（35°C）和有害刺激（49°C）。较高的FMI评分与较低的疼痛强度（p =.005）和疼痛不愉快评分（p =.005）相关。全脑分析显示，较高的气质正念与更大的失活的大脑区域从楔前叶后扣带回皮质（PCC）在有毒的热。这些新的发现表明，正念的人感觉更少的疼痛，并引起更大的大脑区域的失活支持参与感官，认知和情感评价。我们建议，正念和PCC应被视为疼痛治疗的重要机制目标。
Inter–individual differences in pain sensitivity vary as a function of interactions between sensory, cognitive–affective and dispositional factors. Trait mindfulness, characterized as the innate capacity to non–reactively sustain attention to the present moment, is a psychological construct that is associated with lower clinical pain outcomes. Yet, the neural mechanisms supporting dispositional mindfulness are unknown. In an exploratory data analysis obtained during a study comparing mindfulness to placebo–analgesia, we sought to determine if dispositional mindfulness is associated with lower pain sensitivity. We also aimed to identify the brain mechanisms supporting the postulated inverse relationship between trait mindfulness and pain in response to noxious stimulation. We hypothesized that trait mindfulness would be associated with lower pain and greater deactivation of the default mode network. Seventy–six, meditation–naïve and healthy volunteers completed the Freiburg Mindfulness Inventory (FMI) and were administered innocuous (35°C) and noxious stimulation (49°C) during perfusion–based functional magnetic resonance imaging. Higher FMI ratings were associated with lower pain intensity (p =.005) and pain unpleasantness ratings (p =.005). Whole brain analyses revealed that higher dispositional mindfulness was associated with greater deactivation of a brain region extending from the precuneus to posterior cingulate cortex (PCC) during noxious heat. These novel findings demonstrate that mindful individuals feel less pain and evoke greater deactivation of brain regions supporting the engagement sensory, cognitive and affective appraisals. We propose that mindfulness and the PCC should be considered as important mechanistic targets for pain therapies.
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影响因子：
7.4
作者：
Emerson NM;Zeidan F;Lobanov OV;Hadsel MS;Martucci KT;Quevedo AS;Starr CJ;Nahman-Averbuch H;Weissman-Fogel I;Granovsky Y;Yarnitsky D;Coghill RC
通讯作者：
Coghill RC
影响因子：
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作者：
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DOI：
10.1097/00004647-199802000-00003
发表时间：
1998-02-01
影响因子：
6.3
作者：
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通讯作者：
Iadarola, MJ
影响因子：
2
作者：
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通讯作者：
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