Renal function, bisphenol A, and alkylphenols: results from the National Health and Nutrition Examination Survey (NHANES 2003-2006).
Renal function, bisphenol A, and alkylphenols: results from the National Health and Nutrition Examination Survey (NHANES 2003-2006).
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DOI：
10.1289/ehp.1002572
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发表时间：
2011-04
影响因子：
10.4
通讯作者：
Dai Q
中科院分区：
文献类型：
--
作者：
You L;Zhu X;Shrubsole MJ;Fan H;Chen J;Dong J;Hao CM;Dai Q
尿中双酚A(BPA)和烷基酚(APs)的排泄量在以往的研究中被用作生物标志物，但还没有研究这些环境酚的尿排泄量是否因肾功能不同而不同。我们评估了肾功能与尿BPA和AP排泄量之间的关系。分析使用了2003-2006年的国家健康和营养检查调查(NHANES)的数据。肾功能以肾小球滤过率(EGFR)为指标，由肾脏疾病饮食改良(MDRD)研究方程和新开发的慢性肾脏疾病流行病学协作(CKD-EPI)方程计算。在调整潜在的混杂因素后，用回归模型计算按EGFR类别(≥90、60-90和60毫升/分/平方米)排出的双酚A和AP的几何平均数。当我们使用MDRD研究方程时，没有已知肾脏疾病的参与者(n=2,573)，58.2%(n=1,499)的参与者有轻度肾功能下降或未被诊断为慢性肾脏疾病。调整后的双酚A排泄量几何平均数随着EGFR水平的降低而减少(趋势p=0.04)。这种关联主要出现在女性中(趋势的p=0.03)。男性和女性的尿三氯生排泄量都随着EGFR水平的降低而减少(趋势p；0.01)，这种关联主要出现在65岁的参与者中。当我们使用CKD-EPI方程时，BPA和EGFR之间的关联没有显著意义。尿三氯生的排泄量，可能还有双酚A，随着肾功能的下降而减少。这种联系可能因年龄或性别而异。有必要进行进一步的研究，以复制我们的结果并了解其机制。
Urinary excretion of bisphenol A (BPA) and alkylphenols (APs) was used as a biomarker in most previous studies, but no study has investigated whether urinary excretion of these environmental phenols differed by renal function. We estimated the association between renal function and urinary excretion of BPA and APs. Analyses were conducted using data from the National Health and Nutrition Examination Survey (NHANES) 2003–2006. Renal function was measured as estimated glomerular filtration rate (eGFR) calculated by the Modification of Diet in Renal Disease (MDRD) Study equation and by the newly developed Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Regression models were used to calculate geometric means of urinary BPA and APs excretion by eGFR category (≥ 90, 60–90, < 60 mL/min/m2) after adjusting for potential confounding factors. When we used the MDRD Study equation, participants without known renal disease (n = 2,573), 58.2% (n = 1,499) had mildly decreased renal function or undiagnosed chronic kidney disease. The adjusted geometric means for urinary BPA excretion decreased with decreasing levels of eGFR (p for trend = 0.04). The associations appeared primarily in females (p for trend = 0.03). Urinary triclosan excretion decreased with decreasing levels of eGFR (p for trend < 0.01) for both males and females, and the association primarily appeared in participants < 65 years of age. The association between BPA and eGFR was nonsignificant when we used the CKD-EPI equation. Urinary excretion of triclosan, and possibly BPA, decreased with decreasing renal function. The associations might differ by age or sex. Further studies are necessary to replicate our results and understand the mechanism.
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影响因子：
1.9
作者：
Kanno, Yoshihiko;Okada, Hirokazu;Suzuki, Hiromichi
通讯作者：
Suzuki, Hiromichi
影响因子：
10.4
作者：
Calafat AM;Kuklenyik Z;Reidy JA;Caudill SP;Ekong J;Needham LL
通讯作者：
Needham LL
影响因子：
10.4
作者：
Calafat AM;Ye X;Wong LY;Reidy JA;Needham LL
通讯作者：
Needham LL
影响因子：
3.7
作者：
Melzer D;Rice NE;Lewis C;Henley WE;Galloway TS
通讯作者：
Galloway TS
影响因子：
39.2
作者：
Levey, Andrew S.;Coresh, Josef;Van Lente, Frederick
通讯作者：
Van Lente, Frederick