Free-running circadian breathing rhythms are eliminated by suprachiasmatic nucleus lesion.
Free-running circadian breathing rhythms are eliminated by suprachiasmatic nucleus lesion.
复制标题
自由运行的昼夜呼吸节律被视交叉上核病变消除。
DOI：
10.1152/japplphysiol.00211.2020
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Buchanan,GordonF
中科院分区：
文献类型：
--
作者：
Purnell,BentonS;Buchanan,GordonF
人们普遍认为呼吸受昼夜节律调节。呼吸生理的昼夜差异显著影响许多疾病，包括睡眠呼吸暂停、哮喘和癫痫性死亡。一天中的时间对呼吸的影响已经被描述过了；然而，哺乳动物的内源性自由呼吸节律以前没有被描述过。此外，人们假设呼吸的昼夜节律依赖于下丘脑视交叉上核（SCN），即哺乳动物中央昼夜节律振荡器的所在地，但这尚未得到实验证明。在光照-黑暗条件下，每天6次，在持续黑暗条件下，在6个昼夜节律阶段，使用全身脉搏描记仪监测小鼠清醒时的呼吸。呼吸频率和分钟通气量在活动阶段均显著增高，但潮气量不显著增高。为了确定呼吸的昼夜节律调节是否需要SCN，在不同的动物组中，该结构被电解损伤或进行假手术，并在六个不同的时间点测量呼吸。在scn损伤的动物中，呼吸的时间依赖性振荡消失了，但假手术的动物没有。这些结果表明，呼吸受SCN的昼夜节律调节。对呼吸昼夜节律调节的机制见解可能导致有针对性的干预，以减少与呼吸病理生理疾病相关的发病率和死亡率。长期以来，人们一直意识到呼吸是随着一天中的时间而改变的。这项研究表明，呼吸的节律性在持续的黑暗中持续存在，但依赖于下丘脑的视交叉上核。了解呼吸的昼夜节律可能对治疗和预防睡眠呼吸暂停和癫痫猝死等疾病很重要。
It is widely agreed that breathing is subject to circadian regulation. Circadian differences in respiratory physiology significantly impact a number of diseases including sleep apnea, asthma, and seizure-induced death. The effect of time of day on breathing has been previously characterized; however, an endogenous free-running respiratory rhythm in mammals has not previously been described. Furthermore, it is assumed that circadian rhythms in breathing are dependent on the hypothalamic suprachiasmatic nucleus (SCN), the home of the mammalian central circadian oscillator, but this has not been shown experimentally. The breathing of mice was monitored during wakefulness using whole body plethysmography at six times of day while housed under light-dark conditions and at six circadian phases while housed under constant darkness. Respiratory frequency and minute ventilation, but not tidal volume, were significantly higher during the active phase in both entrained and free-running conditions. To determine whether circadian regulation of breathing requires the SCN, in separate sets of animals this structure was electrolytically lesioned bilaterally or a sham surgery was performed, and breathing was measured at six different time points. Time-dependent oscillations in breathing were lost in SCN-lesioned animals, but not those subjected to sham surgery. These results suggest that breathing is subject to circadian regulation via the SCN. Mechanistic insights into the circadian regulation of breathing may lead to targeted interventions to reduce the morbidity and mortality associated with diseases with respiratory pathophysiology.NEW & NOTEWORTHYIt has long been appreciated that breathing is altered by time of day. This study demonstrates that rhythmicity in breathing persists in constant darkness but is dependent on the suprachiasmatic nucleus in the hypothalamus. Understanding circadian rhythms in breathing may be important for the treatment and prevention of diseases such as sleep apnea and sudden unexpected death in epilepsy.
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影响因子：
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DOI：
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期刊：
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影响因子：
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