ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature.
ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature.
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DOI：
10.3389/fmed.2023.1187163
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发表时间：
2023
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
--
作者：
一些患者急性新冠肺炎痊愈后仍有数月不适。他们会出现持续性疲劳、认知问题、头痛、睡眠障碍、肌痛和关节痛、运动后不适、立位不耐受和其他症状，这些症状极大地干扰了他们的功能，可能会让一些人呆在家里，导致残疾。这种疾病(Long COVID)类似于肌痛性脑脊髓炎/慢性疲劳综合征(ME/CFS)，以及可能伴随着各种其他感染源和重大创伤后的持续性疾病。这些疾病加在一起预计将给美国造成数万亿美元的损失。在这篇综述中，我们首先比较了ME/CFS和Long CoVID的症状，注意到它们有相当大的相似之处和少数差异。然后，我们对这两种疾病的潜在病理生理学进行了广泛详细的比较，重点是中枢和自主神经系统、肺、心脏、血管、免疫系统、肠道微生物组、能量代谢和氧化还原平衡的异常。这种比较突出了每种疾病中每种异常的证据是多么有力，并有助于为未来的调查设定优先事项。这篇综述为这两种疾病的潜在生物学方面的广泛文献提供了当前的路线图。
Some patients remain unwell for months after “recovering” from acute COVID-19. They develop persistent fatigue, cognitive problems, headaches, disrupted sleep, myalgias and arthralgias, post-exertional malaise, orthostatic intolerance and other symptoms that greatly interfere with their ability to function and that can leave some people housebound and disabled. The illness (Long COVID) is similar to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) as well as to persisting illnesses that can follow a wide variety of other infectious agents and following major traumatic injury. Together, these illnesses are projected to cost the U.S. trillions of dollars. In this review, we first compare the symptoms of ME/CFS and Long COVID, noting the considerable similarities and the few differences. We then compare in extensive detail the underlying pathophysiology of these two conditions, focusing on abnormalities of the central and autonomic nervous system, lungs, heart, vasculature, immune system, gut microbiome, energy metabolism and redox balance. This comparison highlights how strong the evidence is for each abnormality, in each illness, and helps to set priorities for future investigation. The review provides a current road map to the extensive literature on the underlying biology of both illnesses.
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中脑上升唤醒网络核的回顾以及对肌脑脊髓炎/慢性疲劳综合征（ME/CFS），海湾战争疾病（GWI）（GWI）和运动后不适（PEM）的影响。
影响因子：
3.3
作者：
Baraniuk JN
通讯作者：
Baraniuk JN
影响因子：
3.6
作者：
Wood, Gregory;Kirkevang, Therese Stegeager;Agergaard, Jane;Leth, Steffen;Hansen, Esben Sovso Szocska;Laustsen, Christoffer;Larsen, Anders Hostrup;Jensen, Henrik Kjaerulf;Ostergaard, Lars Jorgen;Botker, Hans Erik;Poulsen, Steen Hvitfeldt;Kim, Won Yong
通讯作者：
Kim, Won Yong
影响因子：
7.4
作者：
Roerink ME;Knoop H;Bronkhorst EM;Mouthaan HA;Hawinkels LJAC;Joosten LAB;van der Meer JWM
通讯作者：
van der Meer JWM
影响因子：
2.9
作者：
通讯作者：
--
DOI：
10.1016/j.nicl.2017.09.024
发表时间：
2018
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Finkelmeyer A;He J;Maclachlan L;Watson S;Gallagher P;Newton JL;Blamire AM
通讯作者：
Blamire AM