Prussian Blue: A Nanozyme with Versatile Catalytic Properties.

Prussian Blue: A Nanozyme with Versatile Catalytic Properties.
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普鲁士蓝:一种具有多种催化性能的纳米酶。

DOI:
10.3390/ijms22115993
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发表时间:
2021-06-01
影响因子:
5.6
通讯作者:
Busquets MA
Busquets MA
中科院分区:
生物学2区
文献类型:
--
作者:
Estelrich J;Busquets MA

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纳米酶是一类具有类酶活性的纳米材料,由于其优异的性能,正成为天然酶的有力竞争者和潜在替代品。纳米酶提供比它们各自的天然酶更好的结构稳定性。因此,纳米酶在不同的领域,如生物医学领域(体内诊断/和治疗)和环境领域(无机和有机污染物的检测和修复)显示出有前途的应用。普鲁士蓝纳米颗粒及其类似物是由交替的三价铁和亚铁离子与氰化物配位组成的金属有机框架(MOF)。这样的纳米颗粒受益于优异的生物相容性和生物安全性。除了其他重要的性质,如高度多孔的结构,普鲁士蓝纳米粒子显示催化活性,由于铁原子作为催化的金属位点。不同的氧化状态负责这种纳米颗粒的多催化活性,即过氧化物酶样,过氧化氢酶样和超氧化物歧化酶样活性。根据催化性能,这些纳米颗粒可以产生或消除活性氧(ROS)。
Nanozymes, nanomaterials with enzyme-like activities, are becoming powerful competitors and potential substitutes for natural enzymes because of their excellent performance. Nanozymes offer better structural stability over their respective natural enzymes. In consequence, nanozymes exhibit promising applications in different fields such as the biomedical sector (in vivo diagnostics/and therapeutics) and the environmental sector (detection and remediation of inorganic and organic pollutants). Prussian blue nanoparticles and their analogues are metal–organic frameworks (MOF) composed of alternating ferric and ferrous irons coordinated with cyanides. Such nanoparticles benefit from excellent biocompatibility and biosafety. Besides other important properties, such as a highly porous structure, Prussian blue nanoparticles show catalytic activities due to the iron atom that acts as metal sites for the catalysis. The different states of oxidation are responsible for the multicatalytic activities of such nanoparticles, namely peroxidase-like, catalase-like, and superoxide dismutase-like activities. Depending on the catalytic performance, these nanoparticles can generate or scavenge reactive oxygen species (ROS).
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