Empirical and theoretical investigation into the potential impacts of insecticide resistance on the effectiveness of insecticide-treated bed nets.
Empirical and theoretical investigation into the potential impacts of insecticide resistance on the effectiveness of insecticide-treated bed nets.
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DOI：
10.1111/eva.12574
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发表时间：
2018-04
影响因子：
4.1
通讯作者：
Thomas MB
中科院分区：
文献类型：
--
作者：
Glunt KD;Coetzee M;Huijben S;Koffi AA;Lynch PA;N'Guessan R;Oumbouke WA;Sternberg ED;Thomas MB
尽管整个非洲媒介蚊子普遍存在杀虫剂抗药性，但有限的证据表明长效杀虫蚊帐 (LLIN) 无法预防疟疾。在这里，我们发现在寻找宿主过程中 LLIN 接触导致抗性按蚊属的死亡率更高。蚊子的数量比使用相同蚊帐的标准实验室暴露所预测的要多。我们还发现，与 LLIN 的亚致死接触会导致实验室和野外多个抗性蚊子系的吸血量减少以及随后的宿主寻找成功。使用传播模型，我们表明，当这些与 LLIN 相关的致死和亚致死效应在蚊子的一生中累积时，它们大大降低了在高净覆盖率条件下耐药性对疟疾传播潜力的影响。如果覆盖率下降，流行病学影响就会更加明显。同样，如果抵抗强度加剧，疟疾控制的损失就会呈非线性增加。我们的研究结果有助于解释为什么杀虫剂耐药性尚未导致 LLIN 的大规模失败，但加强了对替代控制工具和知情耐药性管理策略的呼声。
In spite of widespread insecticide resistance in vector mosquitoes throughout Africa, there is limited evidence that long‐lasting insecticidal bed nets (LLINs) are failing to protect against malaria. Here, we showed that LLIN contact in the course of host‐seeking resulted in higher mortality of resistant Anopheles spp. mosquitoes than predicted from standard laboratory exposures with the same net. We also found that sublethal contact with an LLIN caused a reduction in blood feeding and subsequent host‐seeking success in multiple lines of resistant mosquitoes from the laboratory and the field. Using a transmission model, we showed that when these LLIN‐related lethal and sublethal effects were accrued over mosquito lifetimes, they greatly reduced the impact of resistance on malaria transmission potential under conditions of high net coverage. If coverage falls, the epidemiological impact is far more pronounced. Similarly, if the intensity of resistance intensifies, the loss of malaria control increases nonlinearly. Our findings help explain why insecticide resistance has not yet led to wide‐scale failure of LLINs, but reinforce the call for alternative control tools and informed resistance management strategies.
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影响因子：
3
作者：
Kleinschmidt I;Mnzava AP;Kafy HT;Mbogo C;Bashir AI;Bigoga J;Adechoubou A;Raghavendra K;Knox TB;Malik EM;Nkuni ZJ;Bayoh N;Ochomo E;Fondjo E;Kouambeng C;Awono-Ambene HP;Etang J;Akogbeto M;Bhatt R;Swain DK;Kinyari T;Njagi K;Muthami L;Subramaniam K;Bradley J;West P;Massougbodji A;Okê-Sopoh M;Hounto A;Elmardi K;Valecha N;Kamau L;Mathenge E;Donnelly MJ
通讯作者：
Donnelly MJ
DOI：
10.1098/rspb.2013.0711
发表时间：
2013-07-22
期刊：
Proceedings. Biological sciences
影响因子：
--
作者：
Cator LJ;George J;Blanford S;Murdock CC;Baker TC;Read AF;Thomas MB
通讯作者：
Thomas MB
DOI：
10.1016/s0140-6736(15)00417-1
发表时间：
2016-04-23
期刊：
Lancet (London, England)
影响因子：
--
作者：
Hemingway J;Ranson H;Magill A;Kolaczinski J;Fornadel C;Gimnig J;Coetzee M;Simard F;Roch DK;Hinzoumbe CK;Pickett J;Schellenberg D;Gething P;Hoppé M;Hamon N
通讯作者：
Hamon N
影响因子：
1.9
作者：
Hunt, RH;Brooke, BD;Coetzee, M
通讯作者：
Coetzee, M
影响因子：
6.4
作者：
Alout, Haoues;Yameogo, Bienvenue;Cohuet, Anna
通讯作者：
Cohuet, Anna