Open-field arena boundary is a primary object of exploration for Drosophila.
Open-field arena boundary is a primary object of exploration for Drosophila.
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开放场竞技场边界是果蝇探索的主要对象。
DOI：
10.1002/brb3.36
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发表时间：
2012-03
影响因子：
3.1
通讯作者：
Roman, Gregg
中科院分区：
文献类型：
--
作者：
Soibam, Benjamin;Mann, Monica;Liu, Lingzhi;Tran, Jessica;Lobaina, Milena;Kang, Yuan Yuan;Gunaratne, Gemunu H.;Pletcher, Scott;Roman, Gregg
当成年果蝇被放置在一个新的开阔场地时，最初表现出更高的活动水平，然后是更低的自发活动水平，并且大部分时间都在场地边缘附近，沿着墙壁执行运动。为了确定在探索过程中最初表现出的高活性和跟随墙壁行为的环境特征，我们在不同垂直表面的竞技场中检查了野生型和视觉受损的突变体。这些实验支持这样的结论，即果蝇的沿着墙的行为最好的特征是对竞技场边界的偏好，而不是趋向性或中心恐惧性。在圆形竞技场中，果蝇大多在转角较小的轨迹上运动。由于边界偏好可能来源于高度线性的轨迹，我们进一步开发了一个模拟程序来模拟转弯角度对边界偏好的影响。在一个沙漏形状的竞技场上，凸角的墙壁迫使人们做出直走和顺着墙走的选择，带有约束转弯角度的模拟预测了穿过中央缝隙的一般运动，而果蝇倾向于沿着墙走。因此，低转角运动不会驱动边界偏好。最后，视力受损的果蝇在增强的初始活动的衰减方面表现出缺陷。有趣的是，视觉受损的w1118活动衰退缺陷可以通过增加竞技场边缘的对比度来修复，这表明活动衰退依赖于对边界的视觉检测。因此，竞技场边界是果蝇探索的主要对象。
Drosophila adults, when placed into a novel open-field arena, initially exhibit an elevated level of activity followed by a reduced stable level of spontaneous activity and spend a majority of time near the arena edge, executing motions along the walls. In order to determine the environmental features that are responsible for the initial high activity and wall-following behavior exhibited during exploration, we examined wild-type and visually impaired mutants in arenas with different vertical surfaces. These experiments support the conclusion that the wall-following behavior of Drosophila is best characterized by a preference for the arena boundary, and not thigmotaxis or centrophobicity. In circular arenas, Drosophila mostly move in trajectories with low turn angles. Since the boundary preference could derive from highly linear trajectories, we further developed a simulation program to model the effects of turn angle on the boundary preference. In an hourglass-shaped arena with convex-angled walls that forced a straight versus wall-following choice, the simulation with constrained turn angles predicted general movement across a central gap, whereas Drosophila tend to follow the wall. Hence, low turn angled movement does not drive the boundary preference. Lastly, visually impaired Drosophila demonstrate a defect in attenuation of the elevated initial activity. Interestingly, the visually impaired w1118 activity decay defect can be rescued by increasing the contrast of the arena's edge, suggesting that the activity decay relies on visual detection of the boundary. The arena boundary is, therefore, a primary object of exploration for Drosophila.
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影响因子：
8.2
作者：
Choleris, E;Thomas, AW;Prato, FS
通讯作者：
Prato, FS
影响因子：
8.2
作者：
Eilam, D
通讯作者：
Eilam, D
影响因子：
2.7
作者：
Cardenas, F;Lamprea, MR;Morato, S
通讯作者：
Morato, S
影响因子：
2.5
作者：
CONNOLLY, K
通讯作者：
CONNOLLY, K
影响因子：
2.7
作者：
SIMON, P;DUPUIS, R;COSTENTIN, J
通讯作者：
COSTENTIN, J