Functional Specialization of the Medial Temporal Lobes in Human Recognition Memory: Dissociating Effects of Hippocampal versus Parahippocampal Damage.
Functional Specialization of the Medial Temporal Lobes in Human Recognition Memory: Dissociating Effects of Hippocampal versus Parahippocampal Damage.
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DOI：
10.1093/cercor/bhab290
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发表时间：
2022-04-05
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影响因子：
--
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记忆系统神经科学的一个核心争论是关于不同的内侧颞叶（MTL）结构是否支持识别记忆的不同过程。使用两种识别记忆范式，我们测试了一名罕见的患者（MH），其鼻周病变似乎使海马体免于损伤。与先前类似的病例一致，MH表现出熟悉性受损和保留的回忆。当与海马病变的患者相比，周围皮层似乎没有损伤时，MH在熟悉性方面表现出更大的损伤，而在回忆方面表现出更小的损伤。然而，与健康对照相比，海马体患者的熟悉度也有所下降。然而，当用与患者的连续损伤测量相关的记忆表现分析取代这种传统的患者分类时，海马体体积唯一地预测了回忆，而海马体旁体而不是周围体的体积唯一地预测了熟悉度。我们考虑MH患者和我们的海马病变患者的熟悉性损伤是否源于海马旁皮层（PHC）的“阈下”损伤。我们的数据为识别记忆的双过程模型提供了最令人信服的神经心理学支持，其中回忆和熟悉依赖于不同的MTL结构，并且可能支持PHC在熟悉中的作用。我们的研究强调了通过在更大的患者群体中检查连续的大脑行为关系来补充单例研究的价值。
A central debate in the systems neuroscience of memory concerns whether different medial temporal lobe (MTL) structures support different processes in recognition memory. Using two recognition memory paradigms, we tested a rare patient (MH) with a perirhinal lesion that appeared to spare the hippocampus. Consistent with a similar previous case, MH showed impaired familiarity and preserved recollection. When compared with patients with hippocampal lesions appearing to spare perirhinal cortex, MH showed greater impairment on familiarity and less on recollection. Nevertheless, the hippocampal patients also showed impaired familiarity compared with healthy controls. However, when replacing this traditional categorization of patients with analyses relating memory performance to continuous measures of damage across patients, hippocampal volume uniquely predicted recollection, whereas parahippocampal, rather than perirhinal, volume uniquely predicted familiarity. We consider whether the familiarity impairment in MH and our patients with hippocampal lesions arises from “subthreshold” damage to parahippocampal cortex (PHC). Our data provide the most compelling neuropsychological support yet for dual-process models of recognition memory, whereby recollection and familiarity depend on different MTL structures, and may support a role for PHC in familiarity. Our study highlights the value of supplementing single-case studies with examinations of continuous brain–behavior relationships across larger patient groups.
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影响因子：
5.5
作者：
Huang, Benjamin Y.;Castillo, Mauricio
通讯作者：
Castillo, Mauricio
影响因子：
5.7
作者：
Derner, M.;Dehnen, G.;Fell, J.
通讯作者：
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影响因子：
--
作者：
Bubb, Emma J;Kinnavane, Lisa;Aggleton, John P
通讯作者：
Aggleton, John P
影响因子：
2.6
作者：
Inhoff, Marika C.;Heusser, Andrew C.;Davachi, Lila
通讯作者：
Davachi, Lila
DOI：
10.1073/pnas.0705273104
发表时间：
2007-10-09
影响因子：
11.1
作者：
Bowles, Ben;Crupi, Carina;Kohler, Stefan
通讯作者：
Kohler, Stefan