25-hydroxy vitamin D levels are associated with childhood asthma in a population-based study in Peru.
25-hydroxy vitamin D levels are associated with childhood asthma in a population-based study in Peru.
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DOI：
10.1111/cea.12311
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发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
PURA Study Investigators
中科院分区：
文献类型：
--
作者：
Checkley W;Robinson CL;Baumann LM;Hansel NN;Romero KM;Pollard SL;Wise RA;Gilman RH;Mougey E;Lima JJ;PURA Study Investigators
维生素D缺乏可能与哮喘风险增加有关。我们研究了25-羟基（25-OH）维生素D缺乏症和哮喘患病率之间的关系在两个秘鲁人口接近赤道，但不同程度的城市化。我们在秘鲁两个社区的1441名儿童中进行了一项基于人群的研究，其中1134名（79%）提供了血液样本进行25-OH维生素D分析。在这1134名儿童中，平均年龄为14.8岁; 52%为男孩;哮喘和特应性患病率分别为利马12%和通贝斯3%（p <0.001），利马59%和通贝斯41%（p<0.001）;利马25-OH维生素D平均值为20.8 ng/mL，通贝斯30.1 ng/mL（p<0.001）。利马25-羟基维生素D缺乏症（<20 ng/mL）的患病率为47%，而通贝斯为7%（p<0.001）。在多变量逻辑回归中，我们发现较低的25-OH维生素D水平与哮喘几率增加相关（25-OH维生素D水平每降低10 ng/mL，OR = 1.7，95% CI 1.2至2.6; p<0.01）。在分层分析中，较低的25-OH维生素D水平和哮喘之间的关联仅限于有特应性的儿童（OR=2.2，95%CI 1.3至3.6），而不包括那些没有特应性的儿童（OR=0.9，95%CI 0.5至2.0）。我们没有发现25-OH维生素D水平与其他哮喘临床生物标志物（包括呼出气一氧化氮、血清总IgE和肺功能）之间存在关联。哮喘和25-羟基维生素D缺乏症在利马（南纬12.0°）的儿童中很常见，但在通贝斯（南纬3.6°）的儿童中则不常见。25-OH维生素D缺乏症和哮喘之间的关系在两个地点是相似的，是有限的过敏性儿童。未来的补充试验可能需要考虑分层的特应性在设计时。
Vitamin D deficiency may be associated with an increased risk of asthma. We studied the association between 25-hydroxy (25-OH) vitamin D deficiency and asthma prevalence in two Peruvian populations close to the equator but with disparate degrees of urbanization. We conducted a population-based study in 1441 children in two communities in Peru, of which 1134 (79%) provided a blood sample for 25-OH vitamin D analysis. In these 1134 children, mean age was 14.8 years; 52% were boys; asthma and atopy prevalence were 12% in Lima vs. 3% in Tumbes (p<0.001) and 59% in Lima vs. 41% in Tumbes (p<0.001), respectively; and, mean 25-OH vitamin D was 20.8 ng/mL in Lima vs. 30.1 ng/mL in Tumbes (p<0.001). Prevalence of 25-OH vitamin D deficiency (<20 ng/mL) was 47% in Lima vs. 7% in Tumbes (p<0.001). In multivariable logistic regression, we found that lower 25-OH vitamin D levels were associated with an increased odds of asthma (OR = 1.7 per each 10 ng/mL decrease in 25-OH vitamin D levels, 95% CI 1.2 to 2.6; p<0.01). In stratified analyses, the association between lower 25-OH vitamin D levels and asthma was limited to children with atopy (OR=2.2, 95% CI 1.3 to 3.6) and not in those without atopy (OR=0.9, 95% CI 0.5 to 2.0). We did not find associations between 25-OH vitamin D levels and other clinical biomarkers for asthma, including exhaled nitric oxide, total serum IgE and pulmonary function. Both asthma and 25-OH vitamin D deficiency were common among children living in Lima (latitude=12.0°S) but not among those in Tumbes (3.6°S). The relationship between 25-OH vitamin D deficiency and asthma was similar in both sites and was limited among children with atopy. Future supplementation trials may need to consider stratification by atopy at the time of design.
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影响因子：
5.1
作者：
Chinellato, Iolanda;Piazza, Michele;Boner, Attilio L.
通讯作者：
Boner, Attilio L.
影响因子：
7.1
作者：
Devereux, Graham;Litonjua, Augusto A.;Weiss, Scott T.
通讯作者：
Weiss, Scott T.
影响因子：
24.3
作者：
Chinellato, I.;Piazza, M.;Boner, A. L.
通讯作者：
Boner, A. L.
影响因子：
2.8
作者：
Bener, Abdulbari;Ehlayel, Mohammad S.;Hamid, Qutayba
通讯作者：
Hamid, Qutayba
DOI：
10.1164/rccm.201203-0431oc
发表时间：
2012-07-15
影响因子：
24.7
作者：
Brehm, John M.;Acosta-Perez, Edna;Celedon, Juan C.
通讯作者：
Celedon, Juan C.