Characteristic male urine microbiomes associate with asymptomatic sexually transmitted infection.
Characteristic male urine microbiomes associate with asymptomatic sexually transmitted infection.
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DOI：
10.1371/journal.pone.0014116
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发表时间：
2010-11-24
期刊：
影响因子：
3.7
通讯作者：
Fortenberry JD
中科院分区：
文献类型：
--
作者：
Nelson DE;Van Der Pol B;Dong Q;Revanna KV;Fan B;Easwaran S;Sodergren E;Weinstock GM;Diao L;Fortenberry JD
男性泌尿生殖道的微生物组描述不多，但有人认为男性尿道的细菌定植可能会影响性传播感染（STI）的风险。以前的培养依赖性研究表明，多种非致病性细菌定植在尿道中，但没有彻底表征这些微生物群或建立尿道微生物群组成与STI之间的联系。在这里，我们使用16S rRNA PCR和测序来鉴定从没有尿道炎症症状但STI状态不同的男性收集的尿液标本中的细菌。所有的尿液样本都含有多种细菌属，其中许多含有定植于人类阴道的分类群。与女性生殖道病理学相关的未培养细菌在患有性传播感染的男性标本中大量存在。男性STI患者的尿液微生物组主要由苛养、厌氧和未培养的细菌组成。相同的类群在STI阴性个体中很少见。我们的研究结果表明，男性尿液微生物的组成与STI有关。
The microbiome of the male urogenital tract is poorly described but it has been suggested that bacterial colonization of the male urethra might impact risk of sexually transmitted infection (STI). Previous cultivation-dependent studies showed that a variety of non-pathogenic bacteria colonize the urethra but did not thoroughly characterize these microbiomes or establish links between the compositions of urethral microbiomes and STI. Here, we used 16S rRNA PCR and sequencing to identify bacteria in urine specimens collected from men who lacked symptoms of urethral inflammation but who differed in status for STI. All of the urine samples contained multiple bacterial genera and many contained taxa that colonize the human vagina. Uncultivated bacteria associated with female genital tract pathology were abundant in specimens from men who had STI. Urine microbiomes from men with STI were dominated by fastidious, anaerobic and uncultivated bacteria. The same taxa were rare in STI negative individuals. Our findings suggest that the composition of male urine microbiomes is related to STI.
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影响因子：
9.4
作者：
Forney, Larry J.;Gajer, Pawel;Ravel, Jacques
通讯作者：
Ravel, Jacques
影响因子：
9.4
作者：
CHERNESKY, MA;JANG, D;MAHONY, JB
通讯作者：
MAHONY, JB
影响因子：
14.9
作者：
Chenna, R;Sugawara, H;Thompson, JD
通讯作者：
Thompson, JD
DOI：
10.1111/j.1600-0897.2010.00830.x
发表时间：
2010-07-01
期刊：
American journal of reproductive immunology (New York, N.Y. : 1989)
影响因子：
--
作者：
DiGiulio DB;Romero R;Kusanovic JP;Gómez R;Kim CJ;Seok KS;Gotsch F;Mazaki-Tovi S;Vaisbuch E;Sanders K;Bik EM;Chaiworapongsa T;Oyarzún E;Relman DA
通讯作者：
Relman DA
DOI：
10.1073/pnas.0503236102
发表时间：
2005-05-31
影响因子：
11.1
作者：
Hyman, RW;Fukushima, M;Davis, RW
通讯作者：
Davis, RW