Decafluorobutane as a phase-change contrast agent for low-energy extravascular ultrasonic imaging.
Decafluorobutane as a phase-change contrast agent for low-energy extravascular ultrasonic imaging.
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DOI：
10.1016/j.ultrasmedbio.2011.05.021
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发表时间：
2011-09
影响因子：
2.9
通讯作者：
Dayton, Paul A.
中科院分区：
文献类型：
--
作者：
Sheeran, Paul S.;Wong, Vincent P.;Luois, Samantha;McFarland, Ryan J.;Ross, William D.;Feingold, Steven;Matsunaga, Terry O.;Dayton, Paul A.
目前可用于超声成像和治疗的微泡由于其在微米范围内的尺寸分布而限于血管内空间。相变造影剂（PCCA）已被提出作为克服这种限制的手段，因为在数百纳米尺寸范围内形成的液滴可能能够通过渗漏的微血管外渗，之后它们可以被激活以形成更大的高回声微泡。现有的亚微米尺寸范围的PCCA需要大量的声能蒸发，增加了不必要的生物效应的可能性。因此，需要具有降低的声学活化能的PCCA用于成像研究。在这篇文章中，它表明，十氯丁烷，这通常是在室温下的气体，可以被纳入亚稳液体亚微米液滴与适当的封装方法。所得液滴可用比其它有利的PCCA化合物少得多的能量活化。十氯丁烷纳米液滴可能是一种新的手段，可以安全地将超声成像扩展到血管空间之外。（电子邮件地址：padayton@bme.unc.edu）
Currently available microbubbles used for ultrasound imaging and therapeutics are limited to intravascular space due to their size distribution in the micron range. Phase-change contrast agents (PCCAs) have been proposed as a means to overcome this limitation, since droplets formed in the hundred nanometer size range might be able to extravasate through leaky microvasculature, after which they could be activated to form larger highly echogenic microbubbles. Existing PCCAs in the sub-micron size range require substantial acoustic energy to be vaporized, increasing the likelihood of unwanted bioeffects. Thus, there exists a need for PCCAs with reduced acoustic activation energies for use in imaging studies. In this article, it is shown that decafluorobutane, which is normally a gas at room temperature, can be incorporated into metastable liquid sub-micron droplets with appropriate encapsulation methods. The resulting droplets are activatable with substantially less energy than other favored PCCA compounds. Decafluorobutane nanodroplets may present a new means to safely extend ultrasound imaging beyond the vascular space. (E-mail: padayton@bme.unc.edu)
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影响因子：
8.3
作者：
Hitchcock KE;Holland CK
通讯作者：
Holland CK
影响因子：
3.7
作者：
Fabiilli, Mario L.;Lee, James A.;Kripfgans, Oliver D.;Carson, Paul L.;Fowlkes, J. Brian
通讯作者：
Fowlkes, J. Brian
DOI：
10.1109/tuffc.2005.1503996
发表时间：
2005-07-01
影响因子：
3.6
作者：
Kripfgans, OD;Orifici, CM;Fowlkes, JB
通讯作者：
Fowlkes, JB
DOI：
10.1109/tuffc.2002.1009331
发表时间：
2002-06-01
影响因子：
3.6
作者：
Kripfgans, OD;Fowlkes, JB;Carson, PL
通讯作者：
Carson, PL
DOI：
10.1109/tuffc.2009.1132
发表时间：
2009-05
期刊：
IEEE transactions on ultrasonics, ferroelectrics, and frequency control
影响因子：
--
作者：
Fabiilli ML;Haworth KJ;Fakhri NH;Kripfgans OD;Carson PL;Fowlkes JB
通讯作者：
Fowlkes JB