Association between soy isoflavone intake and breast cancer risk for pre- and post-menopausal women: a meta-analysis of epidemiological studies.
Association between soy isoflavone intake and breast cancer risk for pre- and post-menopausal women: a meta-analysis of epidemiological studies.
复制标题
DOI：
10.1371/journal.pone.0089288
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Yin P
中科院分区：
文献类型：
--
作者：
Chen M;Rao Y;Zheng Y;Wei S;Li Y;Guo T;Yin P
关于绝经前和绝经后妇女摄入大豆异黄酮量与乳腺癌风险之间关系的荟萃分析得出的结论并不完全一致。这些荟萃分析没有探讨在区分绝经前和绝经后妇女的基础上，不同的研究设计对合并结果的影响。我们对35项研究进行了荟萃分析，这些研究报道了绝经前和/或绝经后妇女大豆异黄酮摄入与乳腺癌风险之间的关联结果，分别计算了绝经前和绝经后妇女的合并优势比及其95%可信区间，并在考虑不同研究区域和设计的基础上进一步探讨了大豆异黄酮与乳腺癌的相关性。总结结果表明，大豆异黄酮的摄入对绝经前和绝经后的女性都有预防乳腺癌的作用。然而，他们受到研究设计和地域的影响。在亚洲国家进行的综合OR研究表明，大豆异黄酮的保护作用在绝经前和绝经后妇女中都存在(绝经前妇女的OR = 为0.59，95%CI：0.48-0.69；绝经后妇女的OR = 为0.59，95%CI：0.44-0.74)。然而，来自亚洲国家不同研究设计的结果之间存在一些差异(一致性测试，P = 0.04)。西方国家对绝经后妇女的综合OR研究表明，摄入大豆异黄酮有轻微显著的保护作用(OR = 为0.92；95%CI：0.83∼1.00)，但按研究设计分层的进一步分析发现，没有统计学上的显著关联。我们荟萃分析了更多和更新的研究成果，并根据更年期状况对女性进行分类，以探索大豆异黄酮与乳腺癌的相关性。我们发现，在亚洲国家，摄入大豆异黄酮会降低绝经前和绝经后女性患乳腺癌的风险。然而，对于西方国家的女性来说，无论是绝经前还是绝经后，没有证据表明大豆异黄酮类的摄入与乳腺癌之间存在联系。
Conclusions drawn from meta-analyses on the association between soy isoflavone intake and breast cancer risk for pre- and post-menopausal women are not fully consistent. These meta-analyses did not explore the influence of different study designs on the pooled results on the basis of distinguishing between pre- and post-menopausal women. We performed a meta-analysis of 35 studies which reported results of association between soy isoflavone intake and breast cancer risk for pre- and/or post-menopausal women, calculated pooled odds ratios and their 95% confidence intervals of pre- and post-menopausal women respectively, and further explored soy isoflavone-breast cancer association on the basis of considering different study regions and designs. Summary results suggested that soy isoflavone intake has a protective effect against breast cancer for both pre- and post-menopausal women. However, they are influenced by study design and region. Pooled ORs of studies carried out in Asian countries suggested that soy isoflavone’s protective effect exist in both pre- and post-menopausal women (OR = 0.59, 95%CI: 0.48–0.69 for premenopausal women; OR = 0.59, 95%CI: 0.44–0.74 for postmenopausal women). However, there are some differences between the results pooled from different study designs for women in Asian countries (test for consistency, P = 0.04). Pooled OR of studies on postmenopausal women in Western countries suggested that soy isoflavone intake has a marginally significant protective effect (OR = 0.92; 95%CI: 0.83∼1.00), but further analyses stratifying by study design found no statistically significant association. We meta-analyzed more and newer research results, and separated women according to menopausal status to explore soy isoflavone-breast cancer association. We founded that soy isoflavone intake could lower the risk of breast cancer for both pre- and post-menopausal women in Asian countries. However, for women in Western countries, pre- or post-menopausal, there is no evidence to suggest an association between intake of soy isoflavone and breast cancer.
登录
查看更多内容
DOI：
10.1158/1055-9965.epi-10-0318
发表时间：
2010-07
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Brasky TM;Lampe JW;Potter JD;Patterson RE;White E
通讯作者：
White E
影响因子：
6.4
作者：
Suzuki, Takeshi;Matsuo, Keitaro;Tajima, Kazuo
通讯作者：
Tajima, Kazuo
DOI：
10.1186/bcr1995
发表时间：
2008
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Ward H;Chapelais G;Kuhnle GG;Luben R;Khaw KT;Bingham S;European Prospective into Cancer-Norfolk cohort
通讯作者：
European Prospective into Cancer-Norfolk cohort
影响因子：
7.1
作者：
Lee, Sang-Ah;Shu, Xiao-Ou;Zheng, Wei
通讯作者：
Zheng, Wei
影响因子：
168.9
作者：
LEE, HP;GOURLEY, L;DAY, NE
通讯作者：
DAY, NE