Breast cancer risk in relation to urinary and serum biomarkers of phytoestrogen exposure in the European Prospective into Cancer-Norfolk cohort study.
Breast cancer risk in relation to urinary and serum biomarkers of phytoestrogen exposure in the European Prospective into Cancer-Norfolk cohort study.
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DOI：
10.1186/bcr1995
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
European Prospective into Cancer-Norfolk cohort
中科院分区：
文献类型：
--
作者：
Ward H;Chapelais G;Kuhnle GG;Luben R;Khaw KT;Bingham S;European Prospective into Cancer-Norfolk cohort
植物雌激素是在植物中发现的一组化合物，其结构类似于激素雌二醇，因此具有作为雌激素激动剂或拮抗剂的潜力。它们的潜在影响可能会改变乳腺癌的风险，但在前瞻性队列研究中，只有有限范围的植物雌激素被检查。使用液相色谱/质谱法分析了欧洲癌症前瞻性研究-诺福克队列中237例乳腺癌病例和952例对照个体（年龄45至75岁）的血清和尿液样本中的7种植物雌激素（大豆黄酮、肠二醇、肠内酯、染料木素、黄豆黄素、o-去甲基安哥拉辛和雌马酚）。在招募时收集了参与者的饮食、人口统计学、人体测量学和病史数据。所有模型均根据体重、脂肪和能量摄入、乳腺癌家族史、社会阶层、分析批次以及与雌激素暴露相关的因素进行调整。尿或血清植物雌激素与欧洲前瞻性癌症-诺福克队列中的乳腺癌保护无关。乳腺癌的风险随着尿中总胆固醇水平的升高而略有增加（比值比= 1.08（95%可信区间= 1.00 ~ 1.16），P = 0.055）;在患有雌激素受体阳性肿瘤的患者中，尿雌马酚水平越高，乳腺癌的危险性越高（比值比= 1.07（95%可信区间= 1.01 ~ 1.12），P = 0.013）。在本研究中，植物雌激素生物标志物与乳腺癌风险之间存在关联的证据有限。没有迹象表明植物雌激素生物标志物水平较高会降低乳腺癌的可能性，但观察到一些植物雌激素生物标志物可能与乳腺癌的更大风险相关，需要进一步研究更大的统计功效。
Phytoestrogens are a group of compounds found in plants that structurally resemble the hormone oestradiol, and thus have the potential to act as oestrogen agonists or antagonists. Their potential effects may alter the risk of breast cancer, but only a limited range of phytoestrogens has been examined in prospective cohort studies. Serum and urine samples from 237 incident breast cancer cases and 952 control individuals (aged 45 to 75 years) in the European Prospective into Cancer-Norfolk cohort were analysed for seven phytoestrogens (daidzein, enterodiol, enterolactone, genistein, glycitein, o-desmethylangolensin, and equol) using liquid chromatography/mass spectrometry. Data on participants' diet, demographics, anthropometrics, and medical history were collected upon recruitment. All models were adjusted for weight, fat and energy intake, family history of breast cancer, social class, analytical batch, and factors related to oestrogen exposure. Urinary or serum phytoestrogens were not associated with protection from breast cancer in the European Prospective into Cancer-Norfolk cohort. Breast cancer risk was marginally increased with higher levels of total urinary isoflavones (odds ratio = 1.08 (95% confidence interval = 1.00 to 1.16), P = 0.055); among those with oestrogen receptor-positive tumours, the risk of breast cancer was increased with higher levels of urinary equol (odds ratio = 1.07 (95% confidence interval = 1.01 to 1.12), P = 0.013). There was limited evidence of an association between phytoestrogen biomarkers and breast cancer risk in the present study. There was no indication of decreased likelihood of breast cancer with higher levels of phytoestrogen biomarkers, but the observation that some phytoestrogen biomarkers may be associated with greater risk of breast cancer warrants further study with greater statistical power.
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影响因子：
4.8
作者：
Kuiper, GGJM;Lemmen, JG;Gustafsson, JÄ
通讯作者：
Gustafsson, JÄ
影响因子：
8.4
作者：
Boccardo, F;Lunardi, G;Rubagotti, A
通讯作者：
Rubagotti, A
影响因子：
5
作者：
Hultén, K;Winkvist, A;Hallmans, G
通讯作者：
Hallmans, G
影响因子：
6.4
作者：
Kilkkinen, A;Virtamo, J;Pietinen, P
通讯作者：
Pietinen, P
DOI：
10.1016/s0301-2115(98)00281-4
发表时间：
1999-07-01
影响因子：
2.6
作者：
Brzezinski, A;Debi, A
通讯作者：
Debi, A