A primitive type of renin-expressing lymphocyte protects the organism against infections.
A primitive type of renin-expressing lymphocyte protects the organism against infections.
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DOI：
10.1038/s41598-021-86629-w
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发表时间：
2021-03-31
影响因子：
4.6
通讯作者：
Gomez RA
中科院分区：
文献类型：
--
作者：
Belyea BC;Santiago AE;Vasconez WA;Nagalakshmi VK;Xu F;Mehalic TC;Sequeira-Lopez MLS;Gomez RA
激素肾素在调节血压和液体电解质稳态中起着至关重要的作用。正常情况下，肾素是由肾小球（JG）细胞合成的，JG细胞是位于肾小球入口附近的一组专门的肌上皮细胞。响应于低血压和/或细胞外液体积的减少（当其在脱水、低血压或感染性休克期间发生时），JG细胞通过向循环释放肾素来响应以重建稳态。有趣的是，表达肾素的细胞也存在于肾脏之外，它们的功能仍然是一个谜。我们发现了一种独特类型的表达肾素的B-1淋巴细胞，可能在保护机体免受感染方面具有未被认识的作用。这些细胞合成肾素，捕获和吞噬细菌并控制细菌生长。携带肾素的淋巴细胞控制感染的能力，这是增强了肾素的存在，增加了一个新的，以前未被怀疑的层面的防御作用的肾素表达细胞，连接内分泌控制循环稳态与免疫控制感染，以确保生存。
The hormone renin plays a crucial role in the regulation of blood pressure and fluid-electrolyte homeostasis. Normally, renin is synthesized by juxtaglomerular (JG) cells, a specialized group of myoepithelial cells located near the entrance to the kidney glomeruli. In response to low blood pressure and/or a decrease in extracellular fluid volume (as it occurs during dehydration, hypotension, or septic shock) JG cells respond by releasing renin to the circulation to reestablish homeostasis. Interestingly, renin-expressing cells also exist outside of the kidney, where their function has remained a mystery. We discovered a unique type of renin-expressing B-1 lymphocyte that may have unrecognized roles in defending the organism against infections. These cells synthesize renin, entrap and phagocyte bacteria and control bacterial growth. The ability of renin-bearing lymphocytes to control infections—which is enhanced by the presence of renin—adds a novel, previously unsuspected dimension to the defense role of renin-expressing cells, linking the endocrine control of circulatory homeostasis with the immune control of infections to ensure survival.
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影响因子：
2.2
作者：
Li, Aimin;Wang, Yadong;Zhang, Yali
通讯作者：
Zhang, Yali
影响因子：
3
作者：
Loi, PK;McGraw, HF;Tublitz, NJ
通讯作者：
Tublitz, NJ
影响因子：
4.7
作者：
Fournier, David;Luft, Friedrich C.;Bader, Michael;Ganten, Detlev;Andrade-Navarro, Miguel A.
通讯作者：
Andrade-Navarro, Miguel A.
DOI：
10.1084/jem.20101715
发表时间：
2011-08-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kelly-Scumpia KM;Scumpia PO;Weinstein JS;Delano MJ;Cuenca AG;Nacionales DC;Wynn JL;Lee PY;Kumagai Y;Efron PA;Akira S;Wasserfall C;Atkinson MA;Moldawer LL
通讯作者：
Moldawer LL
影响因子：
20.3
作者：
Khan, Zakir;Shen, Xiao Z.;Bernstein, Kenneth E.
通讯作者：
Bernstein, Kenneth E.