Visuospatial and Sensory Integration Tasks in Patients With Schizophrenia or Schizoaffective Disorder: Relationship to Body Mass Index and Smoking.
Visuospatial and Sensory Integration Tasks in Patients With Schizophrenia or Schizoaffective Disorder: Relationship to Body Mass Index and Smoking.
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DOI：
10.3389/fpsyt.2018.00473
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发表时间：
2018
影响因子：
4.7
通讯作者：
Elman I
中科院分区：
文献类型：
--
作者：
Vanderhoof TS;Gurvits TV;Baker-Nolan JE;Borsook D;Elman I
精神分裂症患者中神经系统软征（NSS）非常普遍，但其病理生理意义尚不清楚。本研究采用了尚未在该患者人群中尝试的感知运动和视觉空间处理测试。对42例精神分裂症或情感性精神障碍患者和10例精神健康者进行了图形复制测验、物体识别测验和道路图测验。与对照组相比，精神分裂症和抑郁症患者复制三维图形（即内克尔和隐藏线消除立方体）和在道路图测试中定位空间的能力显着较差;复制二维图形和对背景噪声的物体识别的组间差异不明显。在精神分裂症/抑郁情感组中，隐藏线消除立方体上的更多错误与更大的体重指数和更严重的尼古丁依赖性（通过尼古丁依赖性的Fagerstrom测试测量）相关。上述发现重复了先前的报告，并将其扩展到不涉及动机和注意力混淆的任务。此外，目前的数据支持的假设，微妙的大脑皮层异常检测特定的NSS测试可能与某些方面的代谢和动机功能的精神分裂症/情感障碍患者。
Neurological soft signs (NSSs) are highly prevalent among patients with schizophrenia, but their pathophysiological significance remains unclear. The present study employed perceptual-motor and visuospatial processing tests that have not yet been attempted in this patient population. Patients with schizophrenia or schizoaffective disorder (n = 42) and mentally healthy subjects (n = 10) were administered Copy Figure Test, Detection and Recognition of an Object Test and Road Map Test. As compared to controls, schizophrenic and schizoaffective patients displayed significantly poorer ability to copy three-dimensional figures (namely, Necker- and hidden line elimination cubes) and to orient in space on a road-map test; group differences in copying two-dimensional figures and on objects' recognition against a background noise were not apparent. In the schizophrenia/schizoaffective group, more mistakes on the hidden line elimination cube was associated with greater body mass index and greater severity of nicotine dependence measured via the Fagerstrom Test of Nicotine Dependence. The above findings replicate those of prior reports and extend them to the tasks that do not involve motivational and attentional confounds. Furthermore, the present data support the hypothesis that subtle cerebral cortical abnormalities detected with specific NSSs tests may be related to some aspects of metabolic and motivational function in patients with schizophrenia/schizoaffective disorder.
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影响因子：
10.6
作者：
通讯作者：
--
影响因子：
10.6
作者：
Contreras-Rodriguez, Oren;Martin-Perez, Cristina;Verdejo-Garcia, Antonio
通讯作者：
Verdejo-Garcia, Antonio
影响因子：
5.4
作者：
Hewlett, Paul;Smith, Andrew;Lucas, Eva
通讯作者：
Lucas, Eva
影响因子：
11.3
作者：
Carter, CS;Robertson, LC;OshoraCelaya, L
通讯作者：
OshoraCelaya, L
DOI：
10.1176/appi.neuropsych.20.4.478
发表时间：
2008-09-01
影响因子：
2.9
作者：
Elman, Igor;Chi, Won H.;Pitman, Roger K.
通讯作者：
Pitman, Roger K.