Synchronous fluorescence determination of ciprofloxacin in the pharmaceutical formulation and human serum based on the perturbed luminescence of rare-earth ions
Synchronous fluorescence determination of ciprofloxacin in the pharmaceutical formulation and human serum based on the perturbed luminescence of rare-earth ions
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基于稀土离子微扰发光的同步荧光测定药物制剂和人血清中的环丙沙星
DOI：
10.1016/j.jlumin.2010.05.034
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发表时间：
2010-11
影响因子：
3.6
通讯作者：
Tong, Changlun
中科院分区：
文献类型：
--
作者：
Fang, Yueheng;Zhuo, Xiajun;Guo, Yun;Tong, Changlun
建立了一种简便、快速、灵敏的同步荧光法测定药物制剂和人血清中环丙沙星的含量。结果表明，在CPFX溶液中加入Y3+后，Y3+的特征荧光消失，而CPFX的荧光强度明显增强。采用同步荧光技术直接测定人血清中的痕量环丙沙星。在1.0 × 10 - 9~5.0 × 10 - 6molL-1范围内，荧光强度与CPFX浓度呈线性关系。方法的检出限（LOD）可达2.0 × 10 - 10molL-1（S/N = 3）。该方法的选择性也很好。临床上常用的金属离子、稀土离子和某些药物在一般条件下不干扰测定。
A simple, rapid and sensitive synchronous fluorescence method was developed for the determination of ciprofloxacin (CPFX) in the pharmaceutical formulation and human serum. The results show that when Y3+is added into the CPFX solution, the characteristic fluorescence of Y3+is not emitted whereas the fluorescence intensity of CPFX is significantly enhanced. The synchronous fluorescence technology is employed in this method to directly determine trace amount of CPFX in human serum. A linear relationship between the fluorescence intensity and the CPFX concentration is obtained in the range of 1.0×10−9∼5.0×10−6molL−1. The limit of detection (LOD) of this method attains as low as 2.0×10−10molL−1(S/N=3). The selectivity of this method is also very good. Common metal ions, rare-earth ions and some pharmaceuticals, which are usually used together with CPFX in the clinic, do not interfere with the determination of CPFX under general conditions.
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DOI：
10.1016/s0731-7085(96)02041-9
发表时间：
1997-08
影响因子：
3.4
作者：
C. Veiopoulou;P. C. Ioannou;E. Lianidou
通讯作者：
C. Veiopoulou;P. C. Ioannou;E. Lianidou
影响因子：
6.2
作者：
Schneider, Marilyn J.;Darwish, Ahmed M.;Freeman, Donald W.
通讯作者：
Freeman, Donald W.
DOI：
10.1016/s0731-7085(02)00105-x
发表时间：
2002-07
影响因子：
3.4
作者：
İ. Süslü;A. Tamer
通讯作者：
İ. Süslü;A. Tamer
影响因子：
6.2
作者：
J. M. Pulgarín;A. A. Molina-A.;P. F. Lopez;I. S. Robles
通讯作者：
J. M. Pulgarín;A. A. Molina-A.;P. F. Lopez;I. S. Robles
DOI：
10.1016/j.saa.2008.03.024
发表时间：
2008-12
期刊：
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
影响因子：
--
作者：
Dan Li;Zheng-yu Yan;Wei-qing Cheng
通讯作者：
Dan Li;Zheng-yu Yan;Wei-qing Cheng