Endophenotypes in schizophrenia: a selective review.
Endophenotypes in schizophrenia: a selective review.
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DOI：
10.1016/j.schres.2009.01.016
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发表时间：
2009-04
影响因子：
4.5
通讯作者：
Pearlson, Godfrey D.
中科院分区：
文献类型：
--
作者：
Allen, Allyssa J.;Griss, Melina E.;Folley, Bradley S.;Hawkins, Keith A.;Pearlson, Godfrey D.
关键词：
鉴于文献中关于精神分裂症内在表型的数据丰富，有一个来源来参考其频率数据是有用的。我们回顾了精神分裂症患者（SCZ）、其一级亲属（REL）和健康对照（HC）在结构和功能磁共振成像（MRI）、感觉处理测量、神经运动能力、神经心理测量和身体特征方面的疾病易感性相关变异的文献。本综述的目的是提供一个最广泛发表的精神分裂症内表型的现有数据的总结。我们在PubMed和MedLine中检索了所有比较SCZ与HC和/或REL与HC组的精神分裂症内在表型的研究。计算每项研究的异常值百分比，通常定义为平均值（异常方向）和/或相关效应量（Cohen’s d）> 2 SD。合并后，文献报告SCZ组平均39.4%（SD=20.7%;范围=2.2-100%）的异常值，REL组28.1%（SD=16.6%;范围=1.6-67.0%）的异常值，HC组10.2%（SD=6.7%;范围=0.0-34.6%）的异常值。这些研究结果进行审查的背景下，新兴的假设精神分裂症内表型，以及各种中间表型之间的聚类趋势的讨论。此外，未来的研究方案进行了讨论，在最近的几个大规模的研究，在患者，亲属和健康对照的多种内表型实例。
Given the wealth of data in the literature on schizophrenia endophenotypes, it is useful to have one source to reference their frequency data. We reviewed the literature on disease-liability associated variants in structural and functional magnetic resonance images (MRI), sensory processing measures, neuromotor abilities, neuropsychological measures, and physical characteristics in schizophrenia patients (SCZ), their first-degree relatives (REL), and healthy controls (HC). The purpose of this review was to provide a summary of the existing data on the most extensively published endophenotypes for schizophrenia. We searched PubMed and MedLine for all studies on schizophrenia endophenotypes comparing SCZ to HC and/or REL to HC groups. Percent abnormal values, generally defined as > 2 SD from the mean (in the direction of abnormality) and/or associated effect sizes (Cohen’s d) were calculated foreach study. Combined, the articles reported an average 39.4% (SD=20.7%; range=2.2-100%) of abnormal values in SCZ, 28.1% (SD=16.6%; range=1.6-67.0%) abnormal values in REL, and 10.2% (SD=6.7%; range=0.0-34.6%) in HC groups. These findings are reviewed in the context of emerging hypotheses on schizophrenia endophenotypes, as well as a discussion of clustering trends among the various intermediate phenotypes. In addition, programs for future research are discussed, as instantiated in a few recent large-scale studies on multiple endophenotypes across patients, relatives, and healthy controls.
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