Development of the preterm infant gut microbiome: a research priority.
Development of the preterm infant gut microbiome: a research priority.
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DOI：
10.1186/2049-2618-2-38
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发表时间：
2014
期刊：
影响因子：
15.5
通讯作者：
Gilbert JA
中科院分区：
文献类型：
--
作者：
Groer MW;Luciano AA;Dishaw LJ;Ashmeade TL;Miller E;Gilbert JA
极低出生体重（VLBW）婴儿由于多种因素（包括破坏正常肠道植物群发育的生理不成熟和产前/产后影响）而具有显著的肠道微生物组生态失调的巨大风险。然而，人们对早产儿生长和成熟过程中微生物群的发育演替知之甚少。本文综述了我们对婴儿肠道微生物组正常发育的理解，并将其与极低出生体重婴儿的微生态失调发育进行了对比。强调人乳在正常肠道微生物发育中的作用，沿着肠道微生物组在免疫发育和胃肠健康中的作用。目前的研究提供的证据表明，肠道微生物组与发育中的婴儿的许多生理系统和代谢过程广泛相互作用。然而，据我们所知，目前还没有研究前瞻性地绘制VLBW婴儿的肠道微生物组。必须填补这一知识空白，使医疗保健系统能够为极低出生体重婴儿的生长、健康和发育提供信息。论文最后推测了VLBW婴儿的肠道微生物组如何通过宿主-微生物相互作用来促进早产后遗症，包括其对婴儿宿主的生长，发育和一般健康的影响。
The very low birth weight (VLBW) infant is at great risk for marked dysbiosis of the gut microbiome due to multiple factors, including physiological immaturity and prenatal/postnatal influences that disrupt the development of a normal gut flora. However, little is known about the developmental succession of the microbiota in preterm infants as they grow and mature. This review provides a synthesis of our understanding of the normal development of the infant gut microbiome and contrasts this with dysbiotic development in the VLBW infant. The role of human milk in normal gut microbial development is emphasized, along with the role of the gut microbiome in immune development and gastroenteric health. Current research provides evidence that the gut microbiome interacts extensively with many physiological systems and metabolic processes in the developing infant. However, to the best of our knowledge, there are currently no studies prospectively mapping the gut microbiome of VLBW infants through early childhood. This knowledge gap must be filled to inform a healthcare system that can provide for the growth, health, and development of VLBW infants. The paper concludes with speculation about how the VLBW infants’ gut microbiome might function through host-microbe interactions to contribute to the sequelae of preterm birth, including its influence on growth, development, and general health of the infant host.
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影响因子：
15.5
作者：
Brown, Christopher T.;Sharon, Itai;Banfield, Jillian F.
通讯作者：
Banfield, Jillian F.
DOI：
10.1073/pnas.1002601107
发表时间：
2010-06-29
影响因子：
11.1
作者：
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作者：
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通讯作者：
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影响因子：
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作者：
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