Independent rate and temporal coding in hippocampal pyramidal cells.

Independent rate and temporal coding in hippocampal pyramidal cells.
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DOI:
10.1038/nature02058
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发表时间:
2003-10-23
期刊:
影响因子:
64.8
通讯作者:
O'Keefe, J
O'Keefe, J
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Huxter, J;Burgess, N;O'Keefe, J

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海马锥体细胞使用时间以及速率编码来信号动物的环境或行为的空间方面。时间代码采取与海马EEG θ节律的并发周期的相位关系的形式(图1)。这两个代码可以分别代表不同的变量。然而,这需要速率和相位可以独立变化,与最近的建议相反,它们是紧密耦合的:两者都反映了细胞输入的幅度。在这里,我们表明,时间的射击和射击率是可分离的,可以代表两个独立的变量,即,动物的位置内的地方字段和它的移动速度通过字段,分别。独立编码的位置连同行动和刺激发生在那里可能有助于解释的双重作用,海马在空间和情节记忆 或在关系/陈述性记忆中的更一般的角色。
Hippocampal pyramidal cells use temporal as well as rate coding to signal spatial aspects of the animal’s environment or behaviour. The temporal code takes the form of a phase relationship to the concurrent cycle of the hippocampal EEG theta rhythm (Figure 1​). These two codes could each represent a different variable. However, this requires that rate and phase can vary independently, in contrast to recent suggestions that they are tightly coupled: both reflecting the amplitude of the cell’s input. Here we show that the time of firing and firing rate are dissociable and can represent two independent variables, viz, the animal’s location within the place field and its speed of movement through the field, respectively. Independent encoding of location together with actions and stimuli occurring there may help to explain the dual roles of the hippocampus in spatial and episodic memory or a more general role in relational/declarative memory.
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