Independent rate and temporal coding in hippocampal pyramidal cells.
Independent rate and temporal coding in hippocampal pyramidal cells.
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DOI:
10.1038/nature02058
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发表时间:
2003-10-23
期刊:
影响因子:
64.8
通讯作者:
O'Keefe, J
中科院分区:
文献类型:
--
作者:
Huxter, J;Burgess, N;O'Keefe, J
Hippocampal pyramidal cells use temporal as well as rate coding to signal spatial aspects of the animal’s environment or behaviour. The temporal code takes the form of a phase relationship to the concurrent cycle of the hippocampal EEG theta rhythm (Figure 1). These two codes could each represent a different variable. However, this requires that rate and phase can vary independently, in contrast to recent suggestions that they are tightly coupled: both reflecting the amplitude of the cell’s input. Here we show that the time of firing and firing rate are dissociable and can represent two independent variables, viz, the animal’s location within the place field and its speed of movement through the field, respectively. Independent encoding of location together with actions and stimuli occurring there may help to explain the dual roles of the hippocampus in spatial and episodic memory or a more general role in relational/declarative memory.
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影响因子:
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DOI:
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